Raised Vaginal Fluid Fibronectin Level Indicates Premature Rupture of Membrane
Journal Title: Journal of Enam Meical College - Year 2012, Vol 2, Issue 2
Abstract
Background: Premature rupture of membrane (PROM) is one of the common complications of pregnancy that has major impact on fetal and neonatal outcome. It is the commonest clinical event where a normal pregnancy becomes suddenly a high-risk one for mother and fetus or neonate. Objective: The study was undertaken to investigate whether raised fibronectin level in vaginal fluid may indicate premature rupture of membrane. Materials and Methods: This cross sectional study was conducted in the department of Obstetrics and Gynecology in Sir Salimullah Medical College & Mitford Hospital, Dhaka during the period of January 2006 to December 2007. A total of 114 pregnant women with gestational age 28th week up to 40th week were included. Sixty were PROM (Group I) and 54 were non-PROM (Group II) subjects. Fibronectin in vaginal fluid was measured by an immunochemical reaction by nephelometer. Statistical analysis was done by SPSS version 10.0. Results: The PROM patients had significantly higher concentration of fibronectin (225.77 ± 115.18 ng/mL) compared to that in non-PROM subjects (8.04 ± 16.17 ng/mL) (p < 0.001). Conclusion: It can be concluded that in cases of unequivocal rupture or intactness of the membranes, the result of the fibronectin test corresponds well with the clinical situation. So fibronectin is a sensitive test for detection of amniotic fluid in the vagina.
Authors and Affiliations
Shamima Rahman, Samsad Jahan, Samira Humaira Habib, Nasrin Sultana, Mst Nigar Sultana, Debashish Paul, Amrita Bhowmik, Khodeja Begum
Keywords
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- EP ID EP36150
- DOI https://doi.org/10.3329/jemc.v2i2.12841
- Views 294
- Downloads 0
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