Randomised Control Study of Palonosetron Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting Following Ear and Nose Surgeries under General Anesthesia
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 11
Abstract
ABSTRACT Introduction: Postoperative Nausea and Vomiting (PONV) is defined as any nausea or vomiting that occurs during the first 48 hours after surgery. It is considered as a distressing event following anaesthesia. The incidences of PONV is 25-30% in all post-surgical patients and the incidence of PONV with middle ear surgeries are 50%-80%. Various pharmacological techniques were used to prevent PONV. Five-HT3 receptor antagonists are most commonly used prophylactic agents. Aim: To compare the efficacy and safety of intravenous Palonosetron 75 mcg, and intravenous Dexamethasone 8 mg in preventing PONV. Materials and Methods: Hundred patients of 18-60 years undergoing ear and nose surgeries under general anaesthesia requiring intubation for more than one hour were randomised into two groups of 50 patients each. Group P received 75mcg of palonosetron and Group D received 8 mg of dexamethasone before induction. The incidence of PONV in the two groups was noted using a four point score until 24 hours postoperatively. Results: The overall incidence of PONV in 0-24 hours were maximum in the dexamethasone group with 50% and 20% in palonosetron group. The four point score was higher in dexamethasone group compared to palonosetron group & with statistically significant difference. The requirement of rescue antiemetic medication was 30% in dexamethasone group and 10% in palonosetron group. Conclusion: Our study has shown that palonosetron is more effective in the prevention of PONV without apparent side effects.
Authors and Affiliations
Anju Annie Paul, Sagiev Koshy George, RV Ranjan, Mary Kurien, Athmanathan Mohan, Leenu Grace Ninan, Vinu Mervick Alfred
Keywords
Related Articles
- EP ID EP526253
- DOI 10.7860/JCDR/2018/35379.12265
- Views 39
- Downloads 0
Assessment of Clinical Competence of Interns using Work Place Based Assessment in Ophthalmology Rotational Posting
ABSTRACT Introduction: Acquisition of clinical skills is the main aim of the compulsory clinical rotations during internship. It is left to chance that students acquire clinical skills as there is no formal assessment to...
Osseous Metaplasia in Adenocarcinoma
ABSTRACT Osseous Metaplasia (OM) or heterotopic ossification is a rare phenomenon with unknown aetiology that is characterised by the formation of mature bone elements in the stroma of different tumors. Awareness of this...
Indian Soldiers Need Eye Protection
Combat-related eye injuries entail enormous financial, social and psychological cost. Military Combat Eye Protection (MCEP) decreases both the incidence and severity of eye injuries. Experts have recognised the need for...
Prevalence of Anaemia and Metabolic Syndrome and their Relationship among Postmenopausal Women in Rural West Bengal, India
ABSTRACT Introduction: Metabolic Syndrome (MS) is becoming pandemic very fast. Anaemia continues to be one of the most significant public health issues. Anaemia is often found with the presence of MS, though the pathophy...
Coconut Oil and Virgin Coconut Oil: An Insight into its Oral and Overall Health Benefits
Oral health is of prime importance to all individuals. The traditional use of oil in India for maintenance of good oral hygiene has been mentioned in the Vedic literature since ancient times. Oil pulling therapy also kno...