Randomised controlled trial comparing clinical response between hypo fractionated verses conventional fractionated radiotherapy in early stage Ca Larynx
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 11
Abstract
Aim: The objective of the study is to compare the locoregional control in patients of early Ca larynx treated with hypofractionated versus conventional fractionated radiotherapy. Material and Methods: Patients with histo-pathologically proven cases of early stage Ca larynx (T1N0M0 and T2N0M0) attending Radiotherapy OPD of our institute between November 2015 and November 2016. Total of 30 patients in each arm were allocated and total of 60 patients were enrolled. Result: In this study, the most common site of primary tumor was supraglottic (53.3%) followed by glottis (46.7%). Complete response (CR) in hypofractionated (Arm A) was (96.7%) with a partial response (PR) of (3.3%) versus Complete response (CR) of (93.3%) in conventional fractionated radiotherapy (Arm B) with a partial response (PR) of (6.7%). Locoregional control at median follow-up of 1yr was (93.3%) in hypofractionated radiotherapy (Arm A) and in conventional radiotherapy (Arm B) was of (96.7%) in patients of Early Ca larynx. Conclusion: Most of our patients were Males with stage II disease. Major subsite was supraglottic followed by glottis. In early treatment response assessment response was comparable to similar studies.
Authors and Affiliations
Amitabha Manna
Keywords
Related Articles
- EP ID EP507221
- DOI -
- Views 69
- Downloads 0
Cardiac Auscultation Versus Two-dimensional Trans thoracic Echocardiography in Native Aortic and Mitral Valve diseases in Erbil City
Background: Echocardiography is use for diagnosis and assessment of valvular heart disease as there are many valve diseases that are silent on clinical auscultation. Objective: To identify the sensitivity of auscultation...
Undifferentiated Pleomorphic Sarcoma of Larynx: A Rare Entity with Review of Literature
Sarcomas of the larynx are rare neoplasms that constitute less than 1% of laryngeal malignancies. We describe a rare case of undifferentiated pleomorphic sarcoma of larynx of a 62-year- old male who presented with hoarse...
Extra Pulmonary Tuberculosis- An Overview of Five Cases
Tuberculosis (TB) is commonly found in developing countries but its incidence is considerable in developed countries also. Lung is predominantly affected while extra pulmonary tuberculosis (EPTB) is rarely encountered. A...
Comparison of Various Modes of Fixation in Fracture Shaft of Both Bones Forearm
The Study compares the outcomes of fracture shaft of both bones forearm treated by either intra medullary nailing or dynamic compression plating. Objectives: To compare the functional outcome of 2 different conventional...
A Study on Effect of Indian Classical Music on Brain Activity Using EEG Signals
“Music‘s the medicine of the mind” by John A Logan. One of the way the neuron and synapse will be active is by listening to music regularly and it depends on sound wave heard 1 . While listening to music there is a incre...