Randomised controlled trial of misoprostol alone and mifepristone followed by misoprostol in second trimester medical termination of pregnancy
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 3
Abstract
Introduction: Although the majority of abortions are performed in first trimester, there is still a need for second trimester MTP due to delayed diagnosis of fetal anomalies, financial difficulties in obtaining abortion services and failure to recognize undesired pregnancy in first trimester. Research suggests that with mifepristone pretreatment lower doses of misoprostol may be sufficient to achieve comparable efficacy. However there is little information on optimal medical regimen using mifepristone and misoprostol for second trimester MTP. Objectives: To compare Induction Abortion Interval (IAI), to evaluate completeness of abortion and to assess the safety of drugs. Methodology: This study was prospective comparative Randomized Controlled Trial without blinding where 56 eligible women were randomly divided in to two groups. In study group tablet Mifepristone 200 mg was given orally to the selected women. After 24 hrs, tablet Misoprosotol 400mcg was kept pervaginally every 3 hourly to a maximum of 5 doses. In control group, only tablet Misoprostol 400mcg was kept pervaginally every 3 hourly to a maximum of 5 doses. Results: In Misoprostol alone group mean IAI was 11.18 hrs while in combined group it was 8.51 hrs. In Misoprostol alone group 78.6% cases had complete abortion while in combined group it was 96.4%. Side effects were more common in misoprostol alone group. Conclusion: Using combination of mifepristone and misoprostol is a safe, non invasive method with a high success rate, short IAI, less side effects
Authors and Affiliations
Dr. Snehal Shinde, Dr. R Patange, Dr. Sanjay Patil, Dr. Manisha Laddad, Dr. Vivek Hoskeri, Dr. Habiba Shaikh
Keywords
Related Articles
- EP ID EP584764
- DOI -
- Views 115
- Downloads 0
Identification of novel mutation in VANGL1 gene in patients with myelomeningocele
Background: Neural tube defects are one of the most common birth defects. The most frequent forms of neural tube defects are anencephaly and myelomeningocele (Spina bifida) which occurs due to incomplete closure of neura...
Retrospective evaluation of the complications in patients with traumatic cataract
Background: The main cause of blindness worldwide from the last two decades is reported to be cataract even after advancement in the patterns of diagnosis and treatment. The present study was planned for the assessment o...
Evaluation of the Vitamin D levels and its effect on cognitive function in menopausal women
The present study was planned by enrolling total 40 females. The patients visited to Out Patient Department (OPD) and in-patient department (IPD) in Patna Medical College from Nov 2017 to march 2018.were considered in th...
Study of spectrum of Perforative peritonitis: A prospective study of 300 cases
Background: Perforative peritonitis (PP) is one of the commonest surgical emergencies in Asian countries and India. The PP aetiology in Asian countries remains different from Western countries. Aims and Objectives: The s...
Assessment of serum lipids & proteins in nephrotic syndrome children’s
Nephrotic-range proteinuria is the loss of 3 grams or more per day of protein into the urine or, on a single spot urine collection, the presence of 2 g of protein per gram of urine creatinine. Nephrotic syndrome is the c...