Randomized controlled trial of the impact on the outcome of pneumonia in children receiving Vitamin D supplementation
Journal Title: Pediatric Review: International Journal of Pediatric Research - Year 2018, Vol 5, Issue 3
Abstract
Objective: To study whether vitamin D supplementation in children presenting with pneumonia and severe pneumonia reduce its duration of recovery. Study design: Randomized, Double blind, Placebo-controlled trial. Setting: Paediatric unit of a Teaching hospital. Methods: 80 children between 2 months-5 years with diagnosis of pneumonia and severe pneumonia (as per the WHO definition) admitted over a period of one year were included. Children with features of rickets, severe malnutrition, history of asthma, any underlying medical disorders and vitamin D supplementation over the last 12 months were excluded. Children were randomized to two groups, Intervention group received 300,000 IU of Vitamin D (1ml) and the control group received 1ml of Sterile water as a placebo intra muscularly along with antibiotics and supportive care. Children were monitored for the resolution of symptoms. The two groups were comparable for baseline demographic, socioeconomic, clinical and laboratory parameters. Results: There was no significant difference in time to resolution of symptoms (fever, tachypnea and chest retractions) in Intervention group (3.63±1.27 days) & placebo group (3.6±0.78 days), p=0.933). Conclusion: Supplementation of single high dose (300,000 IU) of vitamin D given intramuscularly have no beneficial effect on the resolution of pneumonia and severe pneumonia in the children of 2months to 5years of age.
Authors and Affiliations
Jagadish K Jingi, Shailesh S Patil, Arunkumar S. Desai
Keywords
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- EP ID EP373822
- DOI 10.17511/ijpr.2018.3.04.
- Views 107
- Downloads 0
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