Ranolazine A true pluripotent cardiovascular drug or jack of all trades, master of none?
Journal Title: Sultan Qaboos University Medical Journal - Year 2018, Vol 18, Issue 1
Abstract
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Although the majority of patients with CVD are treated with interventional procedures, a substantial number require medical therapy in terms of both prognosis and symptomatic relief. However, commonly used agents such as β-blockers and calcium channel blockers reduce blood pressure in patients whose resting pressures are often already low. Ranolazine is a promising agent that does not have significant effects on blood pressure or heart rate. Use of this drug has been documented in various cardiovascular conditions, including ischaemic heart disease, heart failure and arrhythmias. This review article aimed to examine current evidence on the use of ranolazine in various cardiovascular conditions in order to determine whether it is a true pluripotent cardiovascular agent or, on the other hand, a “jack of all trades, master of none.”
Authors and Affiliations
Alice Mezincescu, V. J. Karthikeyan, Sunil K. Nadar
Keywords
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- EP ID EP22852
- DOI 10.18295/squmj.2018.18.01.003
- Views 391
- Downloads 17
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