Rapid Diagnosis of Toxigenic Clostridium difficile in eld erly patients in Tertiary setup
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 7
Abstract
Background: Antibiotics cause diarrhoea due to infection by antibiotic resistant pathogens such as Staphylococcus aureus , Clostridium difficile, Candida albicans , Salmonella, C.perfringens type A, Klebsiella oxytoca, etc. CDAD (Clostridium difficile associated disease) is responsible for 15 - 25% of cases of AAD. 2 C. difficile associated disease (CDAD) is a serious condition with mortality up to 25 p er cent in frail elderly people . 1 The average age of those with CDI is nearly 20 years older than the average age of those with hospitalization for other reasons. 3 Laboratory diagnosis is based on culture and toxin detection in fecal specimens. Culture is very sensitive but if carried out with out toxin testing, may lead to misdiagnosis of CDAD as it detects even asymptomatic cases. 4 C.DIFF QUIK CHEK COMPLETE ® test is a rapid cassette assay that simultaneously detects both glutamate dehydrogenase (GDH) antigen and toxins A & B of C.difficile in fecal specimens. This test when compared to Toxigenic Culture and PCR showed that 88% could be accurately screened as positive or negative. 5 Objective: To approximate the frequency of CDI in elderly patients on antibiotics with diarrhoea, in whom other possible causes are ruled out. Methods: Stool samples of patients from ICUs and surgical wards who were above 65 years of age with diarrhoea who received antibiotics for 7 days or more were tested after ruling out other possible causes of AAD using Enzyme immuno assay test. Results: 32 (64%) samples were GDH antigen positive, 8(16%) were positive both for GDH and toxin.
Authors and Affiliations
Dr Geethu Thomas MBBS MD
Keywords
Related Articles
- EP ID EP521960
- DOI -
- Views 52
- Downloads 0
2 nd Metacarpophalangeal Joint Fracture Dislocation [Kaplan’s Lesion] Operated by open Reduction with Dorsal Approach: A Case Report
The rare complex dislocation of metacarpophalyngeal joint, also called Kaplan’s lesion requires open reduction. In this dislocation, head of metacarpal is buttonholed within the various anatomical structures like capsulo...
Leukemia Cutis with Acute Myelomonocytic Leukemia Presenting As a Benign Appearing Maculopapular Rash: A Rare and Interesting Case Report
A 54 years old male came with the complaints of raised multiple maculopapular lesions involving the forehead and lateral side of the nose. Skin biopsy showed thinning of epidermis and diffuse monomorphic population of in...
Motor Performance of Dominant and Non-dominant Hand in Right-handed and Left-handed Children
Handedness is a trait of unequal distribution of fine motor skills between the right and left hands. Earlier studies showed that the percentage of dominant hand superiority decreased with age, and the non-dominant hand m...
Prognostic Significance of Hematological and Biochemical Parameters in Multiple Myeloma
Background: Multiple myeloma accounts for 1% of all types of malignancies and about 10 % of hematologic malignancies. Several clinical and laboratory variables help us to determine the prognosis of the disease. The prese...
Congestion Index of Portal Vein in the Evaluation of Liver Disease
Introduction: The invention of Doppler has made it possible to study the hemodynamics of blood flow in the human body. Non-alcoholic fatty liver disease (NAFLD), chronic viral hepatitis and alcoholic liver cirrhosis are...