Rare Side Effects of Imatinib – Lichenoid Dermatitis - A Case Report
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: The treatment for gastrointestinal stromal tumors remains surgery and small molecule tyrosine kinase inhibitor like imatinib. Case report: A 54 years adult male with Gastrointestinal stromal tumor (GIST) of small intestine with liver metastases was started on Imatinib. On treatment, the patient developed multiple well defined hyperpigmented plaques associated with pruritus all over the body. Imatinib was suspended which resulted in remission of symptoms. On restarting Imatinib, resurgence of lesions were observed. Skin biopsy revealed it to be lichenoid dermatitis. Patient was treated with topical steroid and after remission of lesions, Imatinib was restarted with periodic escalation of dose from 200mg to 400mg per day which had a stable response of the tumor in primary and secondary sites with maintained remission of skin lesions. Conclusion: This rare side effect of imatinib can be effectively managed with brief suspension of imatinib and steroid therapy.
Authors and Affiliations
Arun Ramanan, Kalaichelvi K, Lakshminarasimhan S
Keywords
Related Articles
- EP ID EP424969
- DOI -
- Views 121
- Downloads 0
Correlation between Body Mass Index and Blood Glucose Levels in Jharkhand Population
Introduction: Obesity is the leading factor in the pathogenesis of health disorders such as hypertension and type-2 diabetes mellitus. Since BMI is the associated with obesity, the present study has been carried out to e...
A Comparative Study to Study the Difference in Effect between Intracuff Saline, Lidocaine and Alkalinized 2% Lidocaine on Emergence Cough, Sore Throat and Hoarseness
Introduction: Targeted delivery of lidocaine to the mucosa in contact with the tracheal tube (ETT) cuff can be used as a method for decreasing tracheal stimuli. The study was conducted to study the benefits by filling th...
Management of Spacing in Maxillary Anterior Teeth by Minimally Invasive Techniques Using Laminate: A Case Report
Introduction: In today's dental practice one of the biggest challenges of the dentist is to restore spacing in anterior teeth when orthodontic treatment is not feasible, because of increasing aesthetic concern and patien...
Knowledge and Attitude of Dental Practitioners Towards Composite Restorations - A Questionnaire based Survey
Introduction: Aesthetically pleasing restorations are much desirable in current day dentistry and efforts have been made to develop a restorative material to suit the patients desires and needs. Composite resins are curr...
Incidence of Citrobacter Urinary Tract Infection in Type 2 Diabetes and its Relationship to Glycemic Control
Introduction: Citrobacter species of the Enterobacteriaceae family, are gram negative bacilli that are commonly found in the intestinal tract. This study aimed to determine the incidence of Citrobacter Urinary tract infe...