Re:-Antibiofilm activity of Streptomyces toxytricini Fz94 against Candida albicans by Sheir and Hafez (2017)
Journal Title: Microbial Biosystems Journal - Year 2017, Vol 2, Issue 2
Abstract
This paper shows a comprehensive study undertaken covering clinical samples of Candida collected from hospital, as well as samples of Streptomyces collected from soils; all of which were inoculated, incubated and monitored over time and at various temperatures to show the greatest analyses in the prevention and destruction of the Candida biofilm-forming fungus. The high inhibition activity of Streptomyces sp. (No.6) against the Candida sp. biofilms has been clearly demonstrated through various screening methods using DNA extraction and the resazurin method; its prevention and destruction modes compared with other antifungals and the evaluation of cytotoxicity for S. toxytricini Fz94 against human lung epithelial cells. In both the prevention mode and the destruction mode, Streptomyces sp. (No.6) showed a higher percentage effect against clinical C. albicans isolates than ketoconazole or metronidazole which showed the lowest in urine, sputum, pus, vaginal swabs and pleural fluids. This study shows great promise, not just for Egypt, but worldwide, in the prevention of both pre and post operative complications involving the use of prosthetics, catheters, joint replacements etc, that may initiate any form of bloodstream infection. Many patients are more susceptible to these forms of infections than others, and when their immune systems have been compromised due to illness, pain or other infection, their vulnerability to further infection increases. As a nurse I find this study fascinating. As the authors state in their conclusion, more chemical studies are required, however, the implications of what they have discovered are so encouraging that further studies in this field would likely generate interest from international medical research institutions. Research in health areas such as this can only bring about positive change.
Authors and Affiliations
Van der Heul TM
Keywords
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- EP ID EP32933
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