Reakcja Niementowskiego
Journal Title: Wiadomości Chemiczne - Year 2015, Vol 69, Issue 5
Abstract
The Niementowski reaction depends on the fusion of anthranilic acid with carbonyl compounds or amides and dates back to the end of the nineteenth century. Numerous variations of the reaction components and modifications of the reaction conditions have appeared in the literature through years. Besides anthranilic acid other synthons including: methyl o-aminobenzoate [25], o-nitrobenzoic acid [26], o-acylaminobenzamide [21], o-aminobenzamide [27], o-aminobenzonitrile [28], isatoic anhydride [29], benzoxasinone [30, 31] have been employed as well. Replacement of the amide component with either amine [9, 32], nitrile [33], imidate [34], thioamide [35], amidine [36], aldehyde [37] or carboxylic acid [28] have also been reported. To increase yield and to reduce the reaction time a number of variables in reaction conditions have been investigated. The best results have been achieved by implementation of a microwave irradiation [38]. The Niementowski reaction and its variants have found widespread use in pharmaceutical and agrochemical fields for the synthesis of compounds containing quinoline and quinazoline systems which are present in a number of natural and synthetic alkaloids [12, 13] and many drugs [1–5].
Authors and Affiliations
Magdalena Łysakowska, Dorota G. Piotrowska
Keywords
Related Articles
- EP ID EP585090
- DOI -
- Views 137
- Downloads 0
Synteza i aktywność biologiczna pochodnych pirolo [3,4-c]pirydyny
Pyrrolo[3,4-c]pyridine is one of the six structural isomers of the bicyclic ring system containing pyrrole moiety condensed with a pyridine nucleus. This review presents most of the literature data about synthetic pyrrol...
Budowa i funkcje układów białkowo-lipidowych
Biomembranes play many structural and functional roles in both prokaryotic and eukaryotic cells [10]. They define compartments, the communication between the inside and outside of the cell. The main components of biomemb...
Adenozyno-5’-o-(n-acylosulfamoilowe) pochodne jako potencjalne leki przeciwgruźlicze
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is the leading bacterial cause of infectious disease mortality. The current WHOapproved treatment for TB involves a three- or four-drug regime...
Borowce jako centra kwasów Lewisa w oddziaływaniach międzycząsteczkowych : porównanie z wiązaniami wodorowymi
The triel bonds are analyzed and compared with the hydrogen bond interaction. The triel bonds belong to the class of interactions that are named as the σ-hole and π-hole bonds. The σ-hole bond is an interaction between t...
Wybrane wtórne metabolity roślinne jako środki przeciwdrobnoustrojowe
One of the oldest achievements of the human thought is the use of plants and plant extracts in therapeutics. Drugs of a plant origin are characterized by multieffects. In recent years, much interest was directed at medic...