Real-World Observations with Dronedarone Compared to Other Anti-Arrhythmic Drugs in Recurrent Atrial Fibrillation
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 5, Issue 9
Abstract
Background: Many clinical trials have shown that dronedarone which is a potent ion channels blocker is effective in the prevention of atrial fibrillation (AF) relapses. Objective: The aim of this report is to evaluate the recurrence of AF and safety during therapy with dronedarone. Methods: From September 2010 to February 2013, 95 patients with recurrent AF were followed by our department. The mean age was 71. Fifty-two were male (55%). All patients were in class NHYA I-II with paroxysmal or persistent AF. Hepatic enzymes were controlled after 1, 3, and 6 months of therapy. Results: Structural heart diseases were present in 90.5% of patients; 9.5% of patients had lone AF. We observed recurrences of AF in 37.9% of patients treated with dronedarone compared with 39% of patients treated with propafenone or flecainide, 35% of patients treated with sotalol and 25% of patients treated with amiodarone. Using log-rank Mantel-Cox test there are no statistical significant differences between dronedarone and IC anti-arrhythmic drugs and sotalol (p 0.743; p 0.868). Conclusion: According to guidelines, dronedarone resulted as effective as other anti-arrhythmic drugs (except amiodarone) in the prevention of AF with the advantage that it may be safely used in a greater number of patients (including elderly patients with structural heart diseases).
Authors and Affiliations
D. Demarie, F. Orlando, M. Imazio, E. Cerrato, R. Belli
Keywords
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- EP ID EP347350
- DOI 10.9734/BJMMR/2015/12626
- Views 42
- Downloads 0
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