Receiver Operator Characteristic Analysis of Biomarkers Evaluation in Diagnostic Research
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 6
Abstract
ABSTRACT Receiver Operator Characteristic (ROC) analysis is the choice of method in evaluation of biomarkers in bioinformatics research. However, there is no single method and also no single accuracy index in evaluating diagnostic tools. This review provides an extensive illustration of different methods of ROC curve analysis that can be used in clinical practice of diagnostic studies. It includes their early use for rating data and the recent developments for quantitative data with a discussion of choice of model selection in parametric ROC analysis compared with non-parametric approach. The relevant methodological issues of these two alternative approaches have been discussed in terms of bias and sampling variability of Area under the curve (AUC) index that may influence on the performance of diagnostic tests. The methods were illustrated with two relevant clinical examples. The semi-parametric and parametric model of mixture of Gaussian is comparable with purely nonparametric approach. The choice between methods depends on practical conveniences unless the presence of severe departure from binormality. The recent new development and the gaps in knowledge concerning their behaviours in actual applications for medical researches and a guideline for future research have been discussed.
Authors and Affiliations
Karimollah Hajian-Tilaki
Keywords
Related Articles
- EP ID EP523969
- DOI 10.7860/JCDR/2018/32856.11609
- Views 46
- Downloads 0
Effect of Ketofol on Pain and Complication after Caesarean Delivery under Spinal Anaesthesia: A Randomized Double-blind Clinical Trial
Introduction: Pain is the key concern of women after caesarean delivery that may interfere with breastfeeding. Aim: The aim of this study was to assess effect of ketofol (ketamine/propofol combination) on pain and compli...
Meningococcal Carriage among College Freshmen in Kashmir, North India- A Single Centre Study
Introduction: Data on the community carriage of meningococci in developing countries are sparse. Knowledge about the same would help identify demographic and socio-behavioural risk factors, the need for infection control...
Associations of Maternal Serum Zonulin and Elements Concentrations with Neonatal Birth Weight: A Case-Control Study
Introduction: Intake of micronutrients and zonulin levels (as a marker for intestinal permeability) during pregnancy can be effective on birth weight of infants. However, no studies have investigated the relationship bet...
Evaluation of Interdental Spaces of the Mandibular Posterior Area for Orthodontic Mini-Implants with ConeBeam Computed Tomography
Introduction: The use of mini-implants has increased in recent years because of their role in absolute anchorage, but the placement sites may affect the success or failure of the procedure, so it is very important to det...
Study of Insomnia, Day Time Sleepiness and Sleep Quality among South Indian Nurses
ABSTRACT Introduction: Good quality and adequate sleep is important for good cognitive, psychological and physical health. Nurses who work closely with patients need to have sound mental and physical health for proper he...