Receiver Operator Characteristic Analysis of Biomarkers Evaluation in Diagnostic Research
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 6
Abstract
ABSTRACT Receiver Operator Characteristic (ROC) analysis is the choice of method in evaluation of biomarkers in bioinformatics research. However, there is no single method and also no single accuracy index in evaluating diagnostic tools. This review provides an extensive illustration of different methods of ROC curve analysis that can be used in clinical practice of diagnostic studies. It includes their early use for rating data and the recent developments for quantitative data with a discussion of choice of model selection in parametric ROC analysis compared with non-parametric approach. The relevant methodological issues of these two alternative approaches have been discussed in terms of bias and sampling variability of Area under the curve (AUC) index that may influence on the performance of diagnostic tests. The methods were illustrated with two relevant clinical examples. The semi-parametric and parametric model of mixture of Gaussian is comparable with purely nonparametric approach. The choice between methods depends on practical conveniences unless the presence of severe departure from binormality. The recent new development and the gaps in knowledge concerning their behaviours in actual applications for medical researches and a guideline for future research have been discussed.
Authors and Affiliations
Karimollah Hajian-Tilaki
Keywords
Related Articles
- EP ID EP523969
- DOI 10.7860/JCDR/2018/32856.11609
- Views 65
- Downloads 0
Dangerous Headache: A Case of Dural Venous Sinus Thrombosis with Protein S Deficiency
Dural Venous Sinus Thrombosis (DVST) is a sporadic cause of headache. DVST is a recherché complication of maxillary sinus infection. Maxillary sinusitis infection may spread directly to orbit via lamina papyracea and it...
Dexmedetomidine as an Additive to Spinal Anaesthesia in Orthopaedic Patients Undergoing Lower Limb Surgeries: A Randomized Clinical Trial Comparing Two Different Doses of Dexmedetomidine
Introduction: Use of dexmedetomidine as an additive to spinal anaesthesia is gaining popularity; but there seems to be no clear consensus on the ideal dose to be used. Because of dose related prolongation of duration of...
Single Tooth Torquing Auxiliary
This paper demonstrates the biomechanics used in orthodontics for the labial movement of a lingually blocked out tooth. Alignment of a lingually blocked out tooth with proper expression of labial root torque is often cha...
Groin Flap in Paediatric Age Group to Salvage Hand after Electric Contact Burn: Challenges and Experience
Introduction: Electric contact burn is characterised by multiple wounds produced by entrance and exit of the current. Hand is most commonly involved in the same and children are particularly susceptible to such accidents...
Unusual Clinical Presentations in Early-Onset Childhood Sarcoidosis: A Correlation or Coincidence?
Sarcoidosis is a multisystem granulomatous disease which frequently affects young adults. Because of its rarity, the exact incidence and prevalence of childhood sarcoidosis is not known. It mostly affects children of old...