RECENT PROSPECTIVE IN ETHOSOMAL DRUG DELIVERY SYSTEM FOR THE TREATMENT OF NEUROBEHAVIOURAL DYSFUNCTIONS
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 3
Abstract
Transdermal drug delivery system was first introduced more than 40 years ago. The technology generated tremendous excitement and interest amongst major pharmaceutical companies in the 1980s and 90s. By the mid to late 1990s, the trend of transdermal drug delivery system merged into larger organizations. Ethosomes are the ethanolic phospholipid vesicles which are used mainly for transdermal delivery of drugs. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes. Ethosomes have become an area of research interest, because of its enhanced skin permeation, improved drug delivery, increased drug entrapment efficiency etc. The purpose of writing this review on ethosomes drug delivery was to compile the focus on the various aspects of ethosomes including their mechanism of penetration, preparation, advantages, composition, characterization, application and marketed product of ethosomes. Characterizations of ethosomes include Particle size, Zeta potential, Differential Scanning Calorimertry, Entrapment efficiency, Surface tension activity measurement, Vesicle stability and Penetration Studies etc. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservior of medication or through body heat melting thin layers of medication embedded in the adhesive. Transdermal drug delivery offers controlled release of the drug into the patient, it enables a steady blood level profile, resulting in reduced systemic side effects and, sometimes, improved efficacy over other dosage forms.
Authors and Affiliations
Manoj Kumar Katual
Keywords
Related Articles
- EP ID EP654662
- DOI -
- Views 187
- Downloads 0
DEMOGRAPHIC CHARACTERISTICS OF HOSPITALIZED CHILDREN WITH FAVISM IN AL-FALLUJAH CITY: A CASE SERIES
Background: Glucose-6-phosphatase dehydrogenase (G6PD) deficiency is one of the most common X-linked inherited pediatric disorder. Acute hemolytic anemia can be developed in children with G6PD deficiency after ingestion...
PNEUMOMEDIASTINUM SECONDARY TO HYPEREMESIS GRAVIDARUM IN THE FIRST TRIMESTER: CASE REPORT
Here we present the case of a 28-year old patient developing pneumomediastinum secondary to hyperemesis gravidarum. Admitted for treatment several times for hyperemesis from the 9th week of pregnancy, when the patient wa...
“EVALUATION OF PLACENTAL THICKNESS AS A SONOLOGICAL INDICATOR FOR ESTIMATION OF GESTATIONAL AGE AND FETAL OUTCOME IN NORMAL SINGLETON PREGNANCY”
Objectives: (1) To correlate placental thickness and fetal weight with gestational age by ultrasonography in normal singleton pregnancy. (2) To evaluate the role of placental thickness in estimation of fetal outcome in t...
PANCHAKARMA UNIQUE THERAPEUTIC APPROACHES CURE DISEASES: REVIEW BASED ON AYURVEDA
Ayurveda is a science of ancient medical system which not only able to cure disease but also provides guideline of healthy living. Ayurveda emphasizes preventative, therapeutic and rejuvenating approaches for the managem...
APOLIPOPROTEIN A5-1131T>C (RS662799) GENE POLYMORPHISM AS A PREDICTOR FOR CORONARY ARTERY DISEASES
Background: Coronary artery disease (CAD) develops when the major blood vessels that supply the heart with blood, oxygen and nutrients (coronary arteries) become damaged. Cholesterol-containing deposits (plaque) in arter...