Recent Trends in Screening and Evaluation Methods of Anticancer Drugs
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
Cancer is one of the major life threatening diseases worldwide. The available anticancer drugs have distinct mechanisms of action which may vary in their effects on different types of normal and cancer cells. Screening methods are routinely and extensively used to reduce cost and time of drug discovery. The traditional anticancer drug screening methods, including animal experiments and cell-based screening assays. Screening methods for the detection of anticancer activity are of importance in order to find solid tumorspecific agents. The screening and evaluation procedures for the development of anticancer agents indicated that the entire process is a rather difficult task. Presently, active compounds are selected by prescreening and screening against transplanted mouse tumors and human tumor xenografts as well as by the in vitro systems. The US National Cancer Institute (NCI) 60 human tumour cell line anticancer drug screen (NCI60) was developed in the late 1980s as an in vitro drug-discovery tool intended to supplant the use of transplantable animal tumours in anticancer drug screening. This screening model give information about the mechanisms of growth inhibition and tumour-cell kill. Recently, its role has changed to that of a service screen supporting the cancer research community. Target-based and cell-based screenings for new anticancer drugs in the molecular targeting period are methods of identifying more selective anticancer drugs. Here I review the development, use and productivity of the screen, highlighting several outcomes that have contributed to advances in cancer chemotherapy. Finally, we discuss primary and secondary in vivo evaluation in experimental chemotherapy.
Authors and Affiliations
C. P Rathod, S. C. Dhawale, R. V. Kshirsagar
Keywords
Related Articles
- EP ID EP222175
- DOI -
- Views 105
- Downloads 0
Formulation and Evaluation of Amlodipine besylate orally disintegrating tablet
Amlodipine besylate is a recognized drug for hypertension therefore development of an ODT of Amlodipine besylate and to evaluate the effect of various superdisintegrants on its disintegration time and release profile was...
Development and Validation of Spectroscopic Method for Simultaneous Estimation of Acebrophylline and Montelukast Sodium in Combined Dosage Form
A novel combination of Acebrophylline and Montelukast Sodium is used in the treatment of chronic obstructive pulmonary disease (COPD) and bronchial asthma. A simple, sensitive, accurate and reproducible spectroscopic met...
DETERMINATION OF CAFFEINE IN RAW AND ROASTED COFFEE BEANS OF ILU ABBA BORA ZONE, SOUTH WEST ETHIOPIA
3 DETERMINATION OF CAFFEINE IN RAW AND ROASTED COFFEE BEANS OF ILU ABBA BORA ZONE, SOUTH WEST ETHIOPIA Kebena Gebeyehu Motora, Tamene Tadesse Beyene Mettu University, Faculty of Natural and Computational Sciences, Depart...
“INFLUENCE OF NSAIDS ON BLOOD PRESSURE IN HYPERTENSIVE PATIENTS UNDER TREATMENT: A CROSS SECTIONAL STUDY”
Raised blood pressure is one of the leading risk factors for global mortality and is estimated to have caused 9.4 million deaths. There are chances of using anti-hypertensives and NSAIDs together with increasing age for...
STABILITY STUDIES OF RIBAVIRIN SYRUP
Ribavirin is an antiviral agent commonly used for the treatment of severe acute respiratory syndrome. The present study investigated the stability of marketed oral Ribavirin syrup. The syrup was subjected to accelerated...