Receptors of mammalian trace amines

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Receptors of mammalian trace amines

Journal Title: The AAPS Journal - Year 2006, Vol 8, Issue 1

Abstract

The discovery of a family of G-protein coupled receptors, some of which bind and are activated by biogenic trace amines, has prompted speculation as to the physiological role of these receptors. Observations associated with the distribution of these trace amine associated receptors (TAARs) suggest that they may be involved in depression, attention-deficit hyperactivity disorder, eating disorders, migraine headaches, and Parkinson's disease. Preliminary in vitro data, obtained using cloned receptors, also suggest a role for TAARs in the function of hallucinogens.

Authors and Affiliations

Anita H. Lewin

Keywords

Trace amine associated receptor TAAR mammalian G-protein coupled receptor ADHD hypothyroidism-associated depression prepulse inhibition

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EP ID EP681647
DOI 10.1208/aapsj080116
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