Recommended reading in population pharmacokinetic pharmacodynamics
Journal Title: The AAPS Journal - Year 2005, Vol 7, Issue 2
Abstract
Developing the skills or expertise to create useful population pharmacokinetic-pharmacodynamic models can be a daunting task-the level of mathematical and statistical complexity is such that newcomers to the field are frequently overwhelmed. A good place to start in learning the field is to read articles in the literature. However, the number of articles dealing with population pharmacokinetic pharmacodynamics is exponentially increasing on a yearly basis, so choosing which articles to read can be difficult. The purpose of this review is to provide a recommended reading list for newcomers to the field. The list was chosen based on perceived impact of the article in the field, the quality of the article, or to highlight some important detail contained within the article. After reading the articles in the list, it is believed that the reader will have a broad overview of the field and have a sound foundation for moredetailed reading of the literature.
Authors and Affiliations
Peter L. Bonate
Keywords
Related Articles
- EP ID EP681862
- DOI 10.1208/aapsj070237
- Views 98
- Downloads 0
Optimization of the Antitumor Activity of Sequence-specific Pyrrolobenzodiazepine Derivatives Based on their Affinity for ABC Transporters
The online version of this article (doi:10.1208/s12248-010-9225-x) contains supplementary material, which is available to authorized users.
Ligand Binding Assays in the 21st Century Laboratory: Automation
Many manufacturers offer well-designed instrument-specific authentication built into the automated system software. Instrument-specific security often contains thorough system tracking and audit trail generation for ensu...
P-gp Inhibition Potential in Cell-Based Models: Which “Calculation” Method is the Most Accurate?
The objective was to directly compare the four different “calculation” methods of assessing P-gp inhibition potential using experimental data obtained from ~60 structurally diverse internal research and m...
Atenolol quantification in human plasma by high-performance liquid chromatography: Application to bioequivalence study
An accurate, precise, and sensitive high-performance liquid chromatography (HPLC) assay was developed for the determination of atenolol in human plasma samples to compare the bioavailability of 2 atenolol tablet (50 mg)...
Making the Most of Clinical Data: Reviewing the Role of Pharmacokinetic-Pharmacodynamic Models of Anti-malarial Drugs
Mechanistic within-host models integrating blood anti-malarial drug concentrations with the parasite-time profile provide a valuable decision tool for determining dosing regimens for anti-malarial treatments, as well as...