Recovery Profile of Atracurium versus Cisatracurium
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 2
Abstract
ABSTRACT Introduction: Atracurium and cisatracurium are promising drugs offering a predictable recovery due to non-organ dependent elimination. However, due to the variability in metabolism and narrow therapeutic window, monitoring of neuromuscular functions has significant importance. Aim: To compare the onset time, duration of block and recovery indices of atracurium and cisatracurium in equipotent doses. The secondary aim included comparing haemodynamic profile and signs of histamine release. Materials and Methods: The present study was a prospective randomised observational study conducted in the Department of Anaesthesia, Government Medical College, Amritsar, Punjab, India (December 2016 to March 2017). It comprised of 60 ASA Grade I patients in the age group of 18-65 years posted for elective laparoscopic cholecystectomies. Patients were divided into two groups of 30 each. Group C (Cisatracurium) patients received cisatracurium 0.1 mg/kg as loading dose while Group A (Atracurium), patients were administered atracurium 0.5 mg/kg. The onset time, duration of block and recovery index were recorded using Train of Four (TOF) response along with the haemodynamic profile and signs of histamine release, using SPSS 22.0 software considering a p-value<0.05 as significant. Results: The onset time, duration and recovery index in Group A were found to be 168.60±13.44 seconds, 37.12±7.62 minutes and 14.63±1.84 minutes and in Group C, they were recorded to be 181.03±21.76 seconds, 40.37±7.04 minutes and 15.30±1.96 minutes respectively. The haemodynamic profiles in both the groups were comparable and no signs of histamine release were observed. Conclusion: Atracurium has a shorter time of onset as compared to cisatracurium in equipotent dose (2xED95) (p-value<0.01). However, the duration of neuromuscular blockade and the recovery profile of both the drugs were comparable.
Authors and Affiliations
Harpreet Kaur
Keywords
Related Articles
- EP ID EP522280
- DOI 10.7860/JCDR/2018/30686.11190
- Views 79
- Downloads 0
Prognostic Significance of Epidermal Growth Factor Receptor in Patients of Glioblastoma Multiforme
Introduction: Glioblastoma Multiforme (GBM) is the most aggressive glial tumour with hallmark characteristics of rampant proliferation of glial cells along with high pleomorphism, necrosis, endothelial proliferation and...
CBNAAT Co-Testing of Sputum and BAL Fluid with Sputum Microscopy: May it Halt the March of Tuberculosis !
ABSTRACT Introduction: Growing concern for Tuberculosis (TB) epidemic forces World Health Organization (WHO) and government of India (GOI) to incorporate newer rapid and highly specific diagnostic test like Cartridge Bas...
Alexidine: a Safer and an Effective Root Canal Irrigant than Chlorhexidine
Introduction: Chlorhexidine (CHX) is generally used as the final irrigating solution in root canal therapy. Recent studies have reported that, toxic precipitates containing parachloroaniline (PCA) are formed when CHX rea...
Does Treatment of Fistula-in-Ano by Ligation of Intersphincteric Fistula Tract Offer any Advantage over Standard Fistulectomy or Fistulotomy?
ABSTRACT Introduction: Standard surgical treatment of trans-sphincteric fistulae by fistulectomy or fistulotomy has a morbidity of leaving a large perianal wound which needs prolonged care and has risk of incontinence an...
Comparative Efficiency of Muscle Energy Technique and Static Stretching in Enhancing Triceps Surae Flexibility
ABSTRACT Introduction: Flexibility is termed as resilience and painless extensibility of a joint. The reduced flexibility will lead to decreased performance and results in abnormal coordination of movements. To prevent s...