Reduction of Cardiovascular Responses to Laryngoscopy and Intubation by Employing MgSO4 Vs Normal Saline - A Comparative Study
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 1
Abstract
Endotracheal intubation is often associated with a hypertension and tachycardia. Intravenous MgSO4 is a popular method of blunting this response, because of its ability to depress sympathoadrenal response & catacholamine release. Objective: it was undertaken to compare the effects of 50mg/kg MgSO4 IV given 3 minutes before laryngoscopy and intubation. Methods: A sample size of 60 patients aged 18 to 60 yrs were included in the study and they were allocated into 2 groups of n=30 each. Group I served as control. Group II received 50 mg/ kg of IV magnesium sulphate 3 min before induction. HR, SBP were recorded preoperatively, 30 sec, 1 min, 3min & 5min after intubation . Results: Patient receiving iv MgSO4 had a better intubating conditions (p<0.04) statistically significant than in Group I. There was an increase in the HR at 1 minute after intubation compared to basal value (p < 0.01 ). Also, a decrease in SBP observed at 1 minute and 3 min after intubation when compared with basal value (p<0.001) and (p<0.001) respectively. The decrease in RPP at 1 minute & 3 minutte after intubation when compared with the basal value (p <0.001)& (p<0.01) respectively. Conclusion: Magnesium sulphate 50 mg/kg IV infusion 3 minutes before induction, is a simple, effective and practical method of blunting cardiovascular responses to tracheal intubation, not associated with any adverse effect.
Authors and Affiliations
C. K. Ramdas
Keywords
Related Articles
- EP ID EP462191
- DOI 10.21088/ijaa.2349.8471.4117.2
- Views 122
- Downloads 0
Efficacy of Epidural Ropivacaine with Fentanyl as Postoperative Analgesia in Total Knee Replacement Surgeries
ontext: Ropivacaine is a new agent introduced recently which can provide differential blockade. It has been reported to produce greater degree of analgesia at the same time producing lesser motor blockade compared to bup...
The Antacid and Analgesic Efficacy of Intramuscular Tramadol in Patients Undergoing General Anaesthesia
Pulmonary aspiration during induction of general anaesthesia is an important cause of anaesthetic mortality and morbidity. Many agents have been tried to reduce this risk. Aim: To assess and compare the antacid and analg...
Study of Effect of Ondansetron in Preventing Hypotension Following Spinal Anaesthesia in LSCS
This randomized double blind study was conducted to know the efficacy of ondansetron as prophylactic agent for reduction in incidence of hypotension and bradycardia in patients undergoing caesarean section under spinal a...
Intubation Sans Relaxant: Propofol VS. Triple Nerve Block
Aims: Methods that avoid use of muscle relaxants during intubation help us when their use would be detrimental to the patient/situation. Here we aim at intubations without muscle relaxants which could be of great signifi...
Hyomental Distance in Neutral and Extension as a Clinically Reliable Predictor of Difficult Airway
Aims: This study was been done with a purpose to evaluating the benifit of the Hyomental Distance [Hmd] neutral and extended position for predicting accurately difficult visualization of the larynx (DVL) in normal lookin...