Refractory onychomycosis due to Trichophyton rubrum: combination therapy with itraconazole and terbinafine
Journal Title: Nasza Dermatologia Online - Year 2011, Vol 2, Issue 3
Abstract
Objectives: Evaluate the efficacy and tolerability of itraconazole plus terbinafine for refractory onychomycosis. This is a prospective clinical trial. Patients with proven Trychophyton rubrum onychomycosis of toenails were enrolled; the treatment consisted of weekly administration: itraconazole 200mg/day and terbinafine 250mg/day, for four months. Results: Thirty-two patients with onychomycosis were studied. Twenty-eight cases had distal subungual onychomycosis and 4 total dystrophic onychomycosis. At the end of the follow-up 17/32 patients had clinical and mycologic cure (53.12%), 5 had clinical improvement only (15.6%), and 10 (31.2%) failed. Conclusion: Weekly alternate therapy with itraconazole + terbinafine represents a safe rescue treatment.
Authors and Affiliations
Alexandro Bonifaz, Denisse Vázquez-González, Amado Saúl, Leonel Fierro-Arias, Rosa Ponce-Olivera
Keywords
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