Refusal of Venous Thromboembolism Prophylaxis and Incidence of Thrombosis in Patients with Cystic Fibrosis
Journal Title: Pulmonary Research and Respiratory Medicine – Open Journal - Year 2017, Vol 4, Issue 2
Abstract
Background Patients with cystic fibrosis (CF) are at risk of venous thromboembolism (VTE) during hospitalization but many refuse VTE prophylaxis. Methods A single-center, retrospective medical record review was conducted to determine the refusal rate of pharmacologic VTE prophylaxis in adult patients with CF and to identify any correlation between patients who refused prophylaxis and the incidence of VTE. Results Of the 426 patient encounters screened, 307 were included, representing 144 unique patients, with a mean age of 28.4±8.9 years. Venous thromboembolism prophylaxis was refused in 77.5% of the patient encounters. Refusal rates were similar for both unfractionated heparin and enoxaparin (78.8% vs. 75.0%). Five patients (1.63%) developed a VTE during hospitalization or within 30 days of discharge; all five patients refused VTE prophylaxis. Conclusions The majority of hospitalized patients with CF refused pharmacologic prophylaxis with no difference in refusal between pharmacologic agents, and the combined incidence of VTE was low.
Authors and Affiliations
Nicole L. Metzger
Keywords
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- EP ID EP546266
- DOI 10.17140/PRRMOJ-4-138
- Views 208
- Downloads 0
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