Regulation of Protein Degradation and Homeostasis by the Cytokine- Inducible Deubiquitinating Enzymes
Journal Title: International Journal of Immunotherapy and Cancer Research - Year 2018, Vol 4, Issue 1
Abstract
Ubiquitin-proteasome system (UPS) is the major signaling pathway responsible for regulating protein turnover in cells. Deubiquitinating enzymes (DUBs) have an important role in this signaling pathway by eliminating ubiquitins from substrates and inhibiting proteasomal degradation to maintain cellular homeostasis.
Authors and Affiliations
KH Baek
Osteotropism of Breast and Prostate Cancer: Clinical and Experimental Perspective
Breast and prostate cancer are the two most common invasive cancers in women and men, respectively. Although these cancers arise in organs that are different in terms of structure and function, both organs require sexual...
Dalton’s Lymphoma as a Murine Model for Understanding the Progression and Development of T-Cell Lymphoma and Its Role in Drug Discovery
Mouse models are irreplaceable tools for the study of carcinogenesis and the availability of rodent models have enabled rational screening of drugs. Hematological malignancies have been extensively studied in mouse model...
SMART Drug Based Targeted Delivery: A New Paradigm for Nanomedicine Strategies
Introduction: Targeted drug delivery systems are nanoscale drug carrier molecules designed for improving the communication of cellular and molecular components and biodistribution of tumour targeted drug (chemo) therapeu...
Significance of Cancer Stem Cells in Anti-Cancer Therapies
Stem cells are the focus of cutting edge research interest because of their competence both to self-renew and proliferate, and to differentiate into a variety of tissues, offering enticing prospects of growing replacemen...
Probiotics and Bone Health: It takes GUTS to Improve Bone Density
Probiotics are a class of symbiotic bacteria whose administration in adequate amount provides health benefits to the host by altering the composition of gut microbiota. The gut microbiota is known to regulate both the ho...