Regulatory patterns in assessment of functional status of organism of children and adolescents with type 1 diabetes
Journal Title: Український журнал дитячої ендокринології - Year 2018, Vol 0, Issue 1
Abstract
Objective — to further study the original method of assessment of functional status of organism of children and adolescents with type 1 diabetes. Materials and methods. We have examined 23 children with type 1 diabetes and 22 practically healthy schoolchildren. The research was conducted using FAZAGRAF® diagnostic complex. The electrocardiogram (ECG) and heart rate variability (HRV) indices were calculated in a state of rest, at the height of stress and during a period of restitution, which form five classes of distinctive patterns. We determined distribution of patterns in groups. Results and discussion. For AMo and Stress Index the patterns of «Minimum» class are dominant, while for SDNN and RMSSD the patterns of «Maximum» class are dominant. In 26.1 % of afflicted children we observed «Minimum» class patterns atypical for SDNN and in 43.5 % — patterns atypical for RMSSD. There was in afflicted subjects an atypical reaction to stress for pNN50 in 56.5 % of cases, while in healthy ones it was only in 9.5 % of cases (p = 0.95). For Twave symmetry (bТ) we have identified atypical «Increase» patterns in 26.1 % of children with type 1 diabetes, compared to 14.3 % of healthy children. Similar reaction was also observed for standard quadratic deviation of Twave symmetry (SD bT). Conclusions. Identification of atypical patterns, which are descriptive of dynamics of HRV and ECG indices as a result of test with physical stress, in children and adolescents with type 1 diabetes can be considered statistically significant diagnostic marker of myocardial dysfunction.
Authors and Affiliations
V. G. Maidannyk, L. S. Fainzilberg, K. B. Dukkart, A. O. Morozyk, O. S. Kondratiuk
Keywords
Related Articles
- EP ID EP292854
- DOI -
- Views 119
- Downloads 0
Characteristics of clinical picture, diagnosis and treatment of Cushing’s disease in children
In children Cushing’s disease is rare. Growth prognosis, adequacy of development of peak bone mass, development of metabolic complications of the disease all depend on timeliness of diagnosis and treatment. Presented in...
Essential issues of transfer of knowledge and medical technology in pediatric endocrinology
Objective — improvement of information provision for pediatric endocrinologists. Materials and methods. Abstracts of reports for scientific researches (39) and researches (79) conducted in Ukraine in 2001–2017, research...
Geleophysic dysplasia: one gene, different phenotypes
Geleophysic dysplasia (GD) is a rare multisystem disorder that affects bones, joints, heart, and skin. Mode of GD inheritance varies and can be autosomal recessive in case of ADAMTSL2 gene mutations and autosomal dominan...
Treatment optimization inpubertalchildren with syndrome of biologically inactive growth hormone
Objective — to study the effect of analogues of gonadotropin-releasing hormone (aGRH) in combination with recombinant growth hormone (rGH) on the terminal growth of children with the syndrome of bioinactive growth hormon...
Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency an Endocrine Society. Clinical practice guideline. Part 1
-