RELATION BETWEEN PLATELET COUNT, OESOPHAGEAL VARICES AND HEMATEMESIS /MELENA SYMPTOMS IN CIRRHOTIC PATIENTS- A COMPARATIVE STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 13
Abstract
BACKGROUND Cirrhosis of liver is an end stage of chronic liver disease. This is emerging as an important cause of mortality and morbidity worldwide. Different causes of cirrhosis present with similar clinicopathological features, but their clinical course may be different. Alcohol is a leading cause of cirrhosis followed by viral hepatitis, diabetes and other causes. Complication of cirrhosis occurs either due to development of portal hypertension or impaired hepatic synthetic function or both. Complications include gastro-oesophageal varices, ascites, hepatic encephalopathy (HE), hepato-pulmonary hypertension, hepatocellular carcinoma, hepatorenal syndrome, spontaneous bacterial peritonitis, and coagulation disorders. This study was undertaken to determine the prevalence of thrombocytopenia and oesophageal varices among alcoholic liver cirrhosis patients having hematemesis/melena, and to compare it with non-alcoholic cirrhotic patients. METHODS Study was done in the Department of General Medicine, Dhiraj Hospital, Piparia, Vadodara. 90 patients detected with cirrhosis of liver were enrolled in this study. A detailed history, physical examination and necessary investigations were done. RESULTS 35 out of 60 (58.33%) alcoholic patients and 6 out of 30 (20%) non-alcoholic patients had thrombocytopenia. Out of 90 selected patients of cirrhosis of liver, 32 (35.55%) had small while 58 (64.45%) had large oesophageal varices. 40% of those presented with small oesophageal varices had alcoholic liver cirrhosis as underlying cause while 26.67% had non-alcoholic cirrhosis, the difference being statistically significant. CONCLUSION Prevalence of thrombocytopenia in cirrhosis of liver is very common. Significantly more severe thrombocytopenia is found in alcoholic liver cirrhosis patients. Most of the alcoholic patients developed small varices when compared with non-alcoholic patients. Haemorrhagic episodes were less in alcoholic patients.
Authors and Affiliations
Deep Mehta, Santosh Kumar, Ruchit Patel, Jitendra D. Lakhani
Keywords
Related Articles
- EP ID EP615869
- DOI 10.18410/jebmh/2019/219
- Views 71
- Downloads 0
SAFETY AND EFFICACY OF CABERGOLINE ON PREGNANCY OUTCOME IN PATIENTS WITH MICROPROLACTINOMA
BACKGROUND Cabergoline (CAB) has emerged as an effective and well-tolerated drug for the treatment of hyperprolactinemia. However, the drug was included in the pregnancy risk category B by US Food and drug administration...
POST STERILISATION ECTOPIC PREGNANCY IN A TERTIARY CARE CENTRE IN NORTH KERALA
BACKGROUND To study the proportion of ectopic pregnancies with a history of female sterilisation and to assess the risk factors associated with post sterilisation ectopic pregnancy. MATERIALS AND METHODS This is a descri...
A PARTURIENT WITH GESTATIONAL HYPERTENSION AND ANTERIOR PLACENTA PREVIA COMING FOR LSCS DIAGNOSED TO HAVE PERIPARTUM CARDIOMYOPATHY
Peripartum cardiomyopathy is an uncommon but lifethreatening disease that affects women in the last few months of pregnancy or within the first five months after delivery, without previous evidence of heart disease & wit...
THYROID GLAND INVOLVEMENT IN LARYNGEAL AND HYPOPHARYNGEAL CARCINOMA
OBJECTIVES To assess the thyroid gland involvement and the need for thyroidectomy in advanced laryngeal and hypopharyngeal carcinomas that require total laryngectomy. METHODS The study included 47 patients who had underg...
A STUDY OF METABOLIC SYNDROME IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY AT KIMS HOSPITAL, HUBBALLI, KARNATAKA, INDIA
BACKGROUND Coronary heart disease has become an epidemic since 20th century. Deaths due to the same are increasing of around 17.5 million deaths in year 2012. The deaths are increasing more in developing countries and me...