RELATION OF ANTIOXIDANT STATUS AND LIPOPROTEIN (a) LEVEL IN MYOCARDIAL INFARCTION PATIENTS : A CLINICAL STUDY TO EVALUATE THE ANTIOXIDANT/ LIPOPROTEIN (a) RATIO AS A NOVEL PARAMETER TO INDICATE CARDIOVASCULAR ACCIDENT
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 2
Abstract
Lipoprotein (a), a prominent marker of cardiovascular accident, was first described by Berg in 1963(3). Lipoprotein (a) [Lp(a)] has been considered as one of the distinguished signature in myocardial infarction and for many years.1. Owing to incomplete scientific evidence in clinical practice, screening for and treatment of high Lp(a) levels is primarily essential . On the other hand free radicals, now shown to be one of the underlying causes in neurological and immunological diseases, possess tremendous affinity to pair with electrons to form couples. These high velocity reactions have been shown to be the major mechanism behind the harmful effect of free radicals. The present study aims to correlate the antioxidant status ,which has been shown to be associated with kidney, heart and lung diseases, with lipoprotein (a) or Lp (a), The free radicals, basically species with unpaired electrons have been found to be of the causative agents for shifting of equilibrium of pro-oxidant antioxidant balance. Aims and Objectives: Aim of our study is 1.To determine the level of Lp (a) and antioxidant status of patients viz. the antioxidant in vivo parameters like catalase [CAT], superoxide dismutase[SOD] and reduced sulfhydryl group[GSH] 2. To find out the significance of relation between parameters of antioxidant and Lipoprotein (a) level among the patients of cardiovascular accident 3. To compare the Lipoprotein (a) and antioxidant status 4. To find out the significance of Lipoprotein (a) level antioxidant status and correlate the two parameters in acute myocardial infarction [AMI] patients. Materials and Methods: Fourty one (41) patients with acute myocardial infarction were selected from a series of consecutive patients admitted in the coronary care unit (CCU) of different medical colleges and /or hospitals or Nursing Homes or health care centres. Lp(a) was quantified by immunoturbidiometric method and other antioxidant parameters by spectrophotometric /enzymatic assays. Results: Serum LP(a) concentration in control group is 30.50 ± 25 mg/dl with maximum 134mg/dl . In the case group AMI patient group in both male & female patients with average mean LP(a) concentration is 78.95±45 mg/dl, the maximum value is 485 mg/ dl. There is direct correlation between antioxidant enzyme catalase and inverse relationship between superoxide dismutase and reduced sulfhydryl group [Equivalent to reduced glutathione][GSH] Discussion: There is significant difference between the two groups. ( p< 0.05). Lp-(a) concentration level in patients with AMI is higher than the control group. An elevated Lp(a) concentration is associated AMI and a risk factor for AMI ., suggesting that Lp(a) may play an important role in the genesis of thrombotic coronary occlusion and the occurance of AMI. The relationship of antioxidant enzymes proves that the underlying causative agent of pathogenesis of cardiovascular accident is due to ROS[Reactive oxygen species]Conclusion: It is suggested to make Lp(a) serum level determination test as a routine laboratory test for identification of risk factor for AMI .The antioxidant parameters can also be taken as accessory parameters in the detection of CAD. Keywords: LP(a), AMI , catalase, SOD, GSH
Authors and Affiliations
Biswajit Majumdar
Keywords
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