Relation of Vitamin D Supplementation, upto six months of age with Total and Bone Specific Alkaline Phosphatase: A Randomised Control Trial
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 10
Abstract
ABSTRACT Introduction: Vitamin D deficiency is an issue of concern in the Asian population. In the light of the fact that breast milk is an inadequate source of vitamin D, supplementation becomes essential for all term healthy babies for healthy peak bone mass. However, there is a lack of guidelines and research on this issue in India. Aim: To document change in Total Alkaline Phosphatase (TALP) and Bone Specific Alkaline Phosphatase (BSALP) levels in babies receiving 400 IU/day vitamin D from zero to six months (primary objective) and change in vitamin D, PTH, calcium, phosphorus levels and anthropometry (head circumference, length, weight and mid-arm circumference) (secondary objectives). Materials and Methods: Hundred eligible babies were randomised into two groups by block randomisation using alternate sizes of block four and six and allocation concealment was done through serially numbered opaque sealed envelopes. Both groups were followed over six months at intervals of 2, 6, 10 and 14 weeks to compare the change in levels of BSALP and TALP and also vitamin D, PTH, calcium, phosphorus and anthropometry. Results: There was a statistically significant difference in levels of TALP (p<0.001) however, not in BSALP between two groups at six months (p=0.62). There was a significant rise in vitamin D levels in the supplemented group at the end of six months as compared to control group. 60% babies were vitamin D deficient (<20 ng/mL) at birth in the vitamin D group and 34% in the control group while at six months 40% babies were vitamin D deficient in the supplemented group while 76% in controls (p<0.05). No significant difference in anthropometric indices was seen between the two groups. None had vitamin D toxicity. Conclusion: Vitamin D supplementation in newborns for the initial six months led to a significant change in TALP compared to the control group. However, it did not cause a statistically significant change in BSALP. Prevalence of vitamin D deficiency was almost universal in all the mothers. More than half of the newborns delivered to these mothers were also deficient in vitamin D. Vitamin D supplementation significantly reduced the percentage of vitamin D deficient babies in the supplemented group compared to the control group at the end of six months. Vitamin D supplementation in a dose of 400 IU/day was safe and did not lead to any toxicity.
Authors and Affiliations
Hemlata Singh, Arti Maria, Amlin Shukla, Neera Sharma, Kalaivani Mani, Manoj K Das
Keywords
Related Articles
- EP ID EP529346
- DOI 10.7860/JCDR/2018/34751.12095
- Views 62
- Downloads 0
Report Internal Medicine Section Paroxysmal Atrial Fibrillation due to Venomous Snake Bite
Snake bites are common all around the world with a great prevalence in South Asia and the Indian subcontinent. Although they are associated with common complications such as local swelling, bleeding at site of bite, coag...
Pharmacophore Mapping Approach for Drug Target Identification: A Chemical Synthesis and in Silico Study on Novel Thiadiazole Compounds
Introduction: Compounds containing thiadiazole moiety are cognized to possess with variety of clinical and therapeutic activity. Finding a suitable drug target for newly synthesized compounds remain a major bottle neck i...
Spectrophotometric Evaluation of Colour Stability of Nano Hybrid Composite Resin in Commonly Used Food Colourants in Asian Countries
Introduction: There is growing interest in colour stability of aesthetic restorations. So far few studies have been reported. Aim: This study was designed to investigate the effects of different common food colourants i....
Antimicrobial Efficacy of Lipopeptide Antibiotic, Lantibiotic and Cationic Bisbiguanide against Enterococcus faecalis Biofilm: An In-vitro Study
ABSTRACT Introduction: Cyclic lipopeptides, lantibiotics are newer antimicrobials showing promising efficacy against various gram-positive micro-organisms. Daptomycin is a cyclic lipopeptide antibiotic with potent bacter...
Extramedullary Haematopoiesis Presenting as an Adrenal Mass
Images in Medicine