Relationship Between Basic Laboratory Results and Fibrosis in Chronic Hepatitis B Patients
Journal Title: Viral Hepatitis Journal - Year 2019, Vol 25, Issue 2
Abstract
Objectives: Liver biopsy (LB) is an important cornerstone in decision to start treatment for chronic hepatitis B (HB). Viral load and liver function tests are performed to determine the most appropriate time. In this study, factors affecting liver fibrosis in hepatitis B e antigen (HBeAg) negative chronic hepatitis B patients were investigated. Materials and Methods: LB and the other laboratory results such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and hepatitis B virus (HBV)-DNA were collected from patient files, retrospectively. According to study protocol, necroinflammatory scores ≤4 and fibrosis scores ≤1 were accepted as normal liver (NL), and the high value in one of these scores was accepted as chronic hepatitis (CH). Results: A total of 234 patient’s LBs included in the study. A total of 74 (31.6%) patients’ LB was evaluated as NL. In univariate analysis, age, gender, ALT, AST, GGT, AFP and HBV-DNA >100.000 IU/mL, and in multivariate analysis, age, AST level >29 U/L, and AFP level >2.5 ng/mL were the independent risk factors for CH. Conclusion: According to our results, age, AST and AFP predict CH. Doctors who follow up chronic hepatitis B patients should be carefully evaluate these parameters when giving LB decision.
Authors and Affiliations
Ertuğrul Güçlü, Aziz Öğütlü, Mustafa Kösem, Ünal Erkorkmaz, Oğuz Karabay
Keywords
Related Articles
- EP ID EP684554
- DOI 10.4274/vhd.galenos.2019.2019.0010
- Views 159
- Downloads 0
An Evaluation of the Efficacy of High-dose Hepatitis B Vaccine in Patients Using Biological Agents
Objectives: Hepatitis B virus (HBV) vaccination is efficient in the normal population, whereas lower humoral response rates in immunosuppressed patients. Biological agents used in the treatment of several diseases in rec...
Effect of Advanced Fibrosis Presence on Adherence to Hepatocellular Carcinoma Surveillance in Chronic Hepatitis C Patients with Sustained Virologic Response
Objectives: Although hepatocellular carcinoma (HCC) screening is accepted as standard care in patients with chronic hepatitis C (CHC) diagnosis, sustained viral response (SVR) has been obtained by treatment and it is not...
Hepatitis B Surface Antigen Seroprevalence of Turkish and Foreign Patients of Reproductive Age in 2014-2017
Objectives: Cross-country migration may affect the prevalence of hepatitis B virus (HBV). Due to the recent war in Syria, there has been a serious exodus towards Turkey. In this study, it was aimed to investigate the hep...
Which is More Important and Insidious in Dialysis Patients? Occult Hepatitis B or Occult Hepatitis C?
Objectives: The aim of this study was to investigate the presence of occult hepatitis B infection (OBI) and Occult hepatitis C infection (OCI) in hemodialysis patients and to determine whether there is an activation in t...
Evaluating The Frequency of Autoantibodies in Patients with Chronic Hepatitis B
Objectives: The objective of this study is to evaluate the frequency of autoantibodies retrospectively in newly diagnosed chronic hepatitis B (CHB) patients. Materials and Methods: The study was retrospectively conducte...