Relationship between blood dopamine level, behavioral and emotional status of puberty-age children with obesity and normal body mass
Journal Title: Український журнал дитячої ендокринології - Year 2018, Vol 0, Issue 3
Abstract
Objective — to study the relationship between blood dopamine level, emotional and behavioral status depending on body mass index (BMI), sex and puberty stage in children with obesity and normal body mass; to identify risk groups for development of eating disorders and depressed states. Materials and methods. We conducted a prospective study of 106 adolescents (11.6–17.9 years old) by way of questionnaire survey: eating attitudes (EAT26), body image (BI), body satisfaction scale (BSS) and adolescent depression screening scale (depression self-rating scale, DSRC). In 84 of them we identified blood dopamine (D) concentration by way of immunosorbent assay (ELISA). We marked out groups of patients corresponding to BMI SDS: group 1 — those with normal body mass (NBM) (BMI = ±1 SDS; n = 38), 2 — those with alimentary obesity (AO) (BMI ≥ +2 SDS, but < +4 SDS; n = 26) and 3 — those with morbid obesity (MO) (BMI ≥ +4 SDS; n = 42). The children were further divided into subgroups corresponding to sex and sexual development stage according to Tanner. Patients of 2nd and 3rd puberty stage according to Tanner were merged into early puberty (EP) subgroup, those of 4th and 5th stage — into late puberty (LP) subgroup. We have, in accordance with D level, conducted quartile distribution of patients into four groups: group 1 — those with low hormone concentration (< 12.2 pg/ml); 2 — those with moderately decreased concentration (12.2–16.51 pg/ml); 3 — those with moderately increased concentration (16.52–19.83 pg/ml); 4 — those with high concentration (> 19.84 pg/ml). Statistical processing of results was performed by means of SPSS Statistics 21 using Spearman nonparametric correlations, Mann-Whitney, Kruskal-Wallis, Wilcoxon, χ2 criteria and likelihood ratio (LR) (p < 0.05). Results and discussion. Definite reverse causality between blood D concentration, BMI (r = –0.581; p = 0.047) and BMI SDS (r = –0.615; p = 0.033) is established only in boys of 5th puberty stage. Risk of developing eating disorders and altered perception of BI in children of both sexes is equally increased against the background of AO (32 % and 40 %, respectively) and MO (31.4 % and 34.3 %, respectively) and exceeds such risk against the background of NBM (16.2 %, p = 0.038 and 5.4 %, p = 0.0001, respectively). Level of dissatisfaction with the whole body in general group of subjects is the most prominent in the group of patients with MO (35.3 %; p = 0.003). In girls there is negative perception of BI (p = 0.0056), decreased satisfaction with upper and lower body parts (p = 0.038 and p = 0.029, respectively) is noted against the background of AO and intensifies against the background of MO, unlike boys, in whom these parameters and general dissatisfaction with the whole body (p = 0.011; p = 0.001; p = 0.003 and p = 0.002, respectively) are prominent against the background of MO. Frequency of depression (16 %) and depressive episodes (56 %) is maximal in the group of children with AO (p = 0.029). Risk of developing depressive symptoms and signs in children of both sexes increases against high (> 75 ‰) as well as against low (< 25 ‰) blood D concentration (36.4 % and 45.5 %, respectively; p = 0.025). Prominence of eating attitude disorders, negative perception of BI and level of dissatisfaction with the body is maximal in boys with low D level (33.3 %, p = 0.004; 62.5 %, p = 0.017 and 44.4 %, p = 0.05, respectively). Degree of dissatisfaction with the body manifests itself the greatest in girls with high blood D level (> 75 ‰) (41.7 %, p = 0.0395). Against the decrease of blood D level in boys of LP age grows the risk of BI perception alteration (r = –0.435; p = 0.021), degree of dissatisfaction with the whole body (r = –0.397; p = 0.037) and its lower part (r = –0.453; p = 0.015). Conclusions. Established sex- and puberty-related characteristics of connections between blood dopamine, eating attitudes, negative perception of BI, degree of dissatisfaction with the body, frequency of depressive episodes and depression enable us to identify risk groups for development of eating disorders and depressed states in children depending on degree of body mass excessiveness.
Authors and Affiliations
L. S. Viazava, A. V. Solntsava, O. M. Zaytseva
Keywords
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- EP ID EP460807
- DOI 10.30978/UJPE2018-3-4-25
- Views 80
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