Relationship Between Bone Turnover and Bone Density in Perimenopausal and Early Postmenopausal Women
Journal Title: Türkiye Osteoporoz Dünyasından - Year 2009, Vol 15, Issue 1
Abstract
Aim: The aim of this study was to investigate the relationship between the bone turnover and bone density in perimenopausal and postmenopausal women. Material and Methods: Forty-two healthy women, 16 perimenopausal and 26 early postmenopausal were included in the study. Bone density at the spine and proximal femur was measured by dual energy x-ray absorptiometry (DXA). Routine serum biochemical tests were performed. Serum alkaline phosphatase (ALP) level was measured. Bone turnover markers including serum osteocalcin (OC) and and type I collagen crosslinked C-terminal telopeptide (CTX) levels were measured. Results: Mean age was 48±4 years, body mass index (BMI) was 27.87±4.26 kg/m2. Mean age at menopause was 45±9 years, time after menopause was 3.23±1.9 years in early postmenopausal group. Serum OC and CTX levels were 19.23±7.52 mg/dl and 0.58±0.35 mg/dl, respectively. CTX level was high in 21.6% (9 women) of the study subjects, whereas OC level was high in 36.3% (15 women) of the group. Osteoporosis and osteopenia rates in the study subjects were 11.9% and 40.4%, respectively. BMD values at the spine and proximal femur did not show correlation with bone turnover markers. Serum ALP level showed statistically significant negative correlation with femoral neck BMD (p=0.003). BMI showed statistically significant correlation with BMD values at femoral neck and total femur (p=0.033, p=0.001). There were no statistically significant difference in terms of serum OC and CTX levels and BMD values at spine and hip between the perimenopausal and early postmenopausal groups (p>0.05). Conclusion: As our results there was no correlation between bone turnover markers and bone density at spine and hip in perimenauposal and early postmenauposal women. (From the World of Osteoporosis 2009;15:7-10)
Authors and Affiliations
Nurdan Paker, Derya Buğdaycı, Betül Kaya, Didem Dere, Demet Tekdöş
Keywords
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