Relationship between Dietary Acid Load and Glioma: A Case-Control Study
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2019, Vol 13, Issue 1
Abstract
Background and Objectives: Limited data are available on the relationship between dietary factors and risk of glioma. The current study was conducted to investigate the association between dietary acid load (DAL) and risk of glioma in Iranian adults. Methods: This case-control study was carried out on 128 patients with glioma and 256 healthy subjects (Matched for age and sex) in Tehran, Iran. A validated detailed food frequency questionnaire (FFQ) was used to assess dietary intakes of the participants. DAL was estimated using the protein to potassium ratio (Pro/K) and Glioma was diagnosed based on pathological tests. A detailed questionnaire including several non-dietary confounders was also completed. Results: In this study, the participants in the highest tertile of DAL score had a non-significant higher risk of developing glioma as compared to those in the lowest tertile (OR: 1.50; 95% CI: 0.88-2.57). After adjusting the confounding factors, those in the highest tertile of DAL score, were significantly more likely to develop glioma than those in the lowest tertile (OR: 1.87; 95% CI: 1.02-3.45). No significant effect was observed after further adjustment for dietary intakes of meats and processed meats, grains and nuts, fruits, tea, and coffee (OR: 1.97; 95% CI: 1.06, 3.65; p=0.03) and body mass index (OR: 1.96; 95% CI: 1.06, 3.64; p=0.03). Conclusion: The results of this study was indicative of a significant positive association between dietary acid load, as estimated by Pro / K ratio, and risk of developing glioma among adults. Further studies, especially prospective cohorts with long-term follow up, are required to confirm these findings.
Authors and Affiliations
Seyed Mohammad Mousavi, Alireza Milajerdi, Memhdi Sshayanfar, Ahmad Esmaillzadeh
Keywords
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- EP ID EP547684
- DOI 10.29252/qums.13.1.11
- Views 40
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