Relationship Between Frailty and Inflammation
Journal Title: European Journal of Geriatrics and Gerontology - Year 2019, Vol 1, Issue 1
Abstract
Objective: It has been suggested that inflammation plays a role in the pathogenesis of frailty and many studies have been carried out to understand the underlying mechanism. In this study, the relationship between frailty and inflammation was examined. Materials and Methods: Eight hundred and seventeen patients over 65 years of age were evaluated in this study. Comprehensive geriatric assessment was performed in each patient and the Fried frailty criteria were used to assess physical frailty. Neutrophil count, lymphocyte count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), albumin, mean platelet volume and CRP-to-albumin ratio (CAR) and neutrophil-to-lymphocyte ratio (NLR) were recorded as inflammatory markers. Results: The median age of the patients was 73 years (minimum-maximum: 65-94). 61.9% of patients were female (n=506) and 10.8% were frail (n=88). The median CRP was 0.49 mg/L (minimum-maximum: 0.10-7.67) in frail group (p=0.167). The CAR was higher in the frail group but there was no significant correlation between high CAR and frailty (p=0.07). The median NLR was 2.17 (minimum-maximum: 0.21-10.17) in the non-frail group and 2.41 (minimum-maximum: 0.62-18.20) in the frail group and the difference between the two groups was significant (p=0.014). ESR was significantly higher in the frail group (p<0.001). In multivariate analysis, when models with independently related factors were studied, ESR was found to be significantly related with frailty (OR: 1.026, 95% CI: 1.005-1.047, p=0.015). Conclusion: Chronic inflammation has been shown to cause frailty directly or indirectly through its destructive effects on the musculoskeletal, respiratory, and hematological systems as well as other physiological intermediate systems. The findings of this study suggest that there may be a relationship between frailty and inflammation.
Authors and Affiliations
Rana Tuna Doğrul, Hacer Doğan Varan, Muhammet Cemal Kızılarslanoğlu, Mustafa Kemal Kılıç, Güneş Arık, Özgür Kara, Meltem Halil, Mustafa Cankurtaran, Burcu Balam Yavuz
Keywords
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- EP ID EP48036
- DOI 10.4274/ejgg.galenos.2019.29
- Views 314
- Downloads 0
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