Relationship between Haemoglobin Genotype, Incidence of Diabetes Mellitus and Some Clinical Complications in Southern Nigeria Tertiary Health Institutions
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Established association exist between haemoglobin genotype and protection against or susceptibility to some disease conditions. We investigated the relationship between haemoglobin genotypes, incidence of diabetes mellitus and its clinical complications. A cross sectional survey design was adopted for this study; questionnaires were developed and filled accordingly. 445 subjects took part in the study, with 244 making up the test group (diabetics) and 221 as control group (non-diabetics). Subjects were interviewed and samples collected during their weekly clinic visit. Analyses were done to determine the blood sugar concentration in both groups. Data were analyzed using Instat Graph pad 2.5a and Chi-Square. Student T-test were employed to compare two set of data. The result showed that fasting blood sugar (FBS) for the diabetics group was 7.3±0.68mmol/l. Random blood sugar (RBS) for the diabetics group was 18.96±0.089mmol/l and the FBS for the control was 4.2±0.41mmol/l. RBS for the control was 10.1±0.72mmol/l. Diabetics had a significantly higher fasting and random blood sugar concentration than the non-diabetics. The prevalent of diabetes mellitus with AA genotype was significantly higher than patient with AS genotype. Neuromuscular complication was significantly higher than eye complication. Heamoglobin AS appears to offer protection against diabetes mellitus. Eye and neuromuscular complications were most common.
Authors and Affiliations
Okon Uduak Akpan, Akpanyung Edet Okon
Keywords
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- EP ID EP588520
- DOI 10.9790/0853-1601028892
- Views 39
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