Relationship between Il28b Gene Polymorphisms and the Risk of Hepatocellular Carcinoma Development within Vietnamese Hepatitis B Virus Carriers
Journal Title: Journal of Clinical Microbiology and Biochemical Technology - Year 2017, Vol 3, Issue 1
Abstract
IL28B’s SNPs are considered the most important host factors predicting the success of Peg-INF alpha/ribavirin based regimens against Hepatitis C virus (HCV) infection. However, the associations of HBV mediated etiologies have not been well documented. This study investigated the relationship between the three most clinically relevant IL28B SNPs (rs8099917, rs12980275, and rs12979860) with the risk of HBV/HCV infection and HCC development within Vietnamese HBV carriers. By using kinetics and allele specific real-time PCR, the study demonstrated holders of the T/G allele at SNP rs8099917 were less susceptible to HBV/HCV infection. Notably, HBV carriers with the SNP rs8099917 T/G allele were at lower risk of being transformed into HCC. However, because of a small sample size, statistical analysis did not reach significance to demonstrate an association between frequencies of IL28B SNPs and HBV mediated HCC development, even though only the minor allele carriers (either 4 G/G cases of rs8099917 or one T/T case of rs12979860) were recorded in the HCC group.
Authors and Affiliations
Trung Ngo Tat, Giang Dao Phuong, Quyen Dao Thanh, Binh Mai Thanh, Bang Mai Hong, Toan Nguyen Linh, Hoan Phan Quoc, Song Le Huu
Keywords
Related Articles
- EP ID EP353494
- DOI 10.17352/2581-527X.000024
- Views 75
- Downloads 0
Listeria Monocytogenes as a Foodborne Pathogen: Biocontrol in Foods using Lytic Bacteriophages
Foods are playing a significant role in human infections because they are frequent vehicles of some human pathogens, which can spread in a short time to all the animals and are associated with cross contamination during...
An Account of Dengue Epidemics in Central India
Dengue virus is one of most rapidly growing arthropod born viral disease in the world which has serious health and economic implications. Dengue infection can lead to life threating condition with no specific drug or vac...
Identification and Evaluation of In vitro Probiotic Attributes of Novel and Potential Strains of Lactic Acid Bacteria Isolated from Traditional Dairy Products of North-West Himalayas
Background: Fermented dairy products of north-west Himalayas (Himachal Pradesh) are rich sources of potential and novel probiotic isolates which further can be explored for their commercial application. Results: The two...
Membrane and Secretory Protein Extraction of Mycobacterium Tuberculosis and Mycobacterium Bovis Using One Dimensional Electrophoresis (SDS-PAGE)
Background & Aim: Despite the drug resistance M.bovis and Mycobacterium tuberculosis (MTB) are still regarded as two of the global health problems in the world. In the present study, a comparison was made between protein...
Modulation of Immune Response in Edible Fish against Aeromonas hydrophila
The present study was to obtain a basic knowledge of the hematology of Catla catla Post challenged with Aeromonas hydrophila. Fish were fed diets representing different supplementation levels of Aegle marmelos fruit extr...