RELATIONSHIP BETWEEN INSULIN SENSITIVITY, GLUCOSE LEVEL AND ADIPONECTIN LEVEL IN LIVER DISEASED RATS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 6
Abstract
Introduction: The liver has an important role in carbohydrate metabolism since it is responsible for the balance of blood glucose levels by means of glycogenogenesis and glycogenolysis. Aim of the Study: Evaluation of the effect of the single and combined administration of insulin and N-acetyl cysteine on glucose metabolism in hepatotoxic rats. Materials and Methods: This study enrolling 5 groups of adult male albino rats. Hepatotoxicity was induced in group II, III, IV &V using carbon tetrachloride, while group I was left as control. Group II received no treatment, group III received N-acetyl cysteine, group IV received insulin while group V received insulin and N-acetyl cysteine. Samples were taken and measured liver function tests, insulin, glucose and adiponectin level as well as histopathological studies analysis of the liver specimens were measured and non-parametric multicomparison test was applied. Results: Liver function tests, group II and group IV showed higher significant statistical difference than group I and III. Also group II showed higher significant statistical difference than other groups as regarding blood glucose level and adiponectin level. The histopathological results revealed that the untreated group showed significant liver damage when compared to the control group, while treatment with NAC alone and treated with insulin and NAC showed significant reduction of all histopathological changes, whereas treatment with insulin alone significantly reduced all the histopathological changes except lobular inflammation. Conclusion: Good control of carbohydrate metabolism including insulin level, insulin resistance and adiponectin level helped in improving the prognosis of liver dysfuction diseases.
Authors and Affiliations
Dr. Gehad M. Iraqy
Keywords
Related Articles
- EP ID EP636069
- DOI -
- Views 143
- Downloads 0
A RARE CASE OF ELDERLY SUDANESE WOMEN WITH CHOREA RESPONSE TO VITAMIN B12 INJECTION
Introduction: Deficiency of vitamin B12 produces protean effects on the nervous system, most commonly neuropathy, myelopathy, cognitive and behavioral symptoms, and optic atrophy. Involuntary movements comprise a relativ...
VALIDATION OF ASSAY METHOD FOR THE ESTIMATION OF IMATINIB MESYLATE IN TABLET DOSAGE FORM BY HPLC
A simple, sensitive high performance liquid chromatographic method was validated for the estimation of Imatinib Mesylate in pure and in pharmaceutical dosage forms. A 4.6-mm X 150-cm column that contains packing L1 (C18)...
ATTITUDE OF CHRONIC DISEASE PATIENTS TOWARDS THE COST OF THEIR PRESCRIBED MEDICATIONS
Background: Rapid modernization and urbanization in United Arab Emirates have been accompanied by the wide spread of the devastating Serious health problems. Objectives: The main objectives of the study are to identify d...
LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (LC-MS) - AN UPDATE
Mass Spectrometry (MS) is an important analytical tool for molecular research and used around the globe to identify, quantify and characterize biomolecules like proteins from any number of biological conditions or sample...
HANDHELD DEVICES (HHD) USE AMONG FAMILY MEDICINE RESIDENTS IN RIYADH CITY, KSA
Background: Among health care providers, especially physicians, the use of Handheld Devices (HHD) including smartphones and tablets has evolved since the handheld devices technology keeps improving. There are specific ap...