Relationship between Neutrophilto-Lymphocyte Ratio and Stress in Multiple Sclerosis Patients
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
Introduction: Multiple Sclerosis (MS), a disease of autoimmunity and inflammation, is characterized by deterioration of the myelin sheath that protects the nerve fibers. The high levels of neutrophils in serum may be related to the chronic inflammation and caused by other triggers such as infections that have been associated with relapses in MS. Aim: To investigate the value of Neutrophil/Lymphocyte Ratio (NLR) as a possible marker and relationship with Depression, Anxiety and Stress (DAS) score in MS patients. Materials and Methods: A total of 60 MS patients and 60 age and sex matched healthy controls were recruited for the present study. We measured DAS score, NLR, calcium, phosphate, magnesium, chloride, alkaline phosphatase, albumin in serum levels in MS patients and in healthy controls. Results: The mean age was not significantly different in both case and control groups. The case and control groups were similar in terms of sex; however, the majority of the MS group was female. The NLR values of MS patients were significantly higher than those of the healthy controls (p=<0.001). The NLR values were also significantly (p<0.001) correlated with stress score. Conclusion: NLR could be considered as a quick, cheap, easily measurable and inflammatory marker for assessment of inflammation in MS patients. The role of NLR in MS must be explored further.
Authors and Affiliations
Fawaz Al- Hussain, Meshal Mohammed Alfallaj, Abdulaziz Nasser Alahmari, Abdullah Nasser Almazyad, Talal Khalid Alsaeed, Abdulmjeed Abdulaziz Abdurrahman, Ghulam Murtaza, Shahid Bashir
Keywords
Related Articles
- EP ID EP341190
- DOI 10.7860/JCDR/2017/24388.9764
- Views 80
- Downloads 0
Ectopic Ureter Causing Hydrometra in a Case of Cervical Dysgenesis with Vaginal Agenesis
ABSTRACT Cervical agenesis or dysgenesis is the defect of vertical fusion of the mullerian duct and the urogenital sinus. The reported incidence is 0.01% in general population. Up to 53% of patients with mullerian agenes...
Utilisation of Adolescent Health Services Under RMNCH+A in an Urban Slum of Berhampur, Odisha, India
ABSTRACT Introduction: Adolescents constitute 22.3% percent of the global population. Many challenges are faced by the adolescent girls for which adolescent health services under National Rural Health Mission (NRHM) are...
Causative Agents of Mycobacterial Diseases in Aquarium Fish and their Importance for Human Health
ABSTRACT Introduction: The isolation of Non-Tuberculous Mycobacteria (NTM) from human and fish mycobacteriosis specimens increasingly has turned to be a major concern. NTM can cause opportunistic infections in elderly an...
Dengue Haemorrhagic Encephalitis: Rare Case Report with Review of Literature
Dengue is an endemic arboviral infection prevalent especially in tropical countries including Southern and Southeast Asia. Central Nervous System (CNS) involvement in dengue infection is uncommon. Haemorrhagic encephalit...
Peri-operative Inotrope Use in Off Pump Coronary Artery Bypass Graft Surgeries
Introduction: Off-Pump Coronary Artery Bypass Graft (OPCABG) surgery is now widely accepted and practiced. The literature on inotrope use in OPCABG is sparse. Aim: To look into the intra-operative and immediate postopera...