Relationship between selenium and prostate cancer risk; systematic review and meta-analysis and meta-regression
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 8
Abstract
Prostate cancer is one of the five most common cancers in men. It is suspected that selenium protect or exacerbate the risk of prostate cancer. The aim of this study was to determine the association between prostate cancer risk and selenium in the serum, toenail and supplements. So it was tried to do a systematic review and meta-analysis and meta-regression of 22 studies (5 toenail studies, 14 serum studies and 3 supplements studies) in order to obtain detailed results of these studies’ data. Meta-regression results showed that location of study (p value <0.001), type of study (p value = 0.04) and age (p value =0.008) have significant effects on heterogeneity. There was no publication bias in studies (Begger's test: z-value = 1.98; P value=0.067). In general, unlike selenium supplements [OR=0.86 (CI: 0.7-1.06, P value=0.15], selenium increase in serum [OR=0.76 (0.59-0.99, P value=0.04] and toenail [OR=0.58 (0.4-0.86, P value=0.01] significantly decreased the risk of prostate cancer by %24 and 42 %. In general, the odds ratio between prostate cancer caused by selenium in the random effect model OR: 0.71 (CI: 0.59- 0.86%, P value <0.001) and heterogeneity was moderate (I2 = 70.6%, P value <0.001). The results of this study supported the lowering effect of selenium in serum and toenail on the risk of prostate cancer.
Authors and Affiliations
Yadolah Fakhri| Food and Cosmetic Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran, Parviz Kokhaei| Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran, Mahboobeh Moradi| Studends Research Office, Department of Environmental Health Engineering, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Maryam Dadar| Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran, Nazak Amanidaz| Environmental Health Research Center, Golestan University of Medical Sciences, Golestan, Iran, Yahya Zandsalimi| Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran, Bigard Moradi| Department of Health Public, Kermanshah University of Medical Sciences, Kermanshah, Iran, Leila Rasouli Amirhajeloo| Department of Environmental Health Engineering, School of Public Health, Qom University of Medical Sciences, Qom, Iran, Hassan Keramati| Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran Corresponding Email:Hkramatee@gmail.com
Keywords
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