“Relationship between serum concentration of the soluble interleukin-1 receptor family member ST-2 and serial change in left ventricular function after acute myocardial infarction”
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Background: Myocardial infarction continues to be one of the most important cause of mortality and morbidity worldwide. The sequel of infarction may be heart failure, myocardial rupture, various arrhythmias, aneurysm or even death. Early and proper management of myocardial infarction by medical treatment, thrombolysis, percutaneous coronary intervention and coronary artery bypass grafting has improved the outcome to much greater extent in terms of cardiac end point1 . If we could have such biomarkers which not only would increase the diagnostic accuracy but also provide the prognostic information about the concerned disease promptly and in an effective way, serum soluble ST2 is one such biomarker which has the above mentioned qualities. Aim: To find relationship between serum concentration of the ST-2 and serial changes in left ventricular function. Method: This was an observational study involving 30 new cases of AMI .Serum ST-2 was measured at admission and its relation was seen with left ventricular function. Result: We analyzed the relationship of serum soluble ST2 with the ejection fraction at the time of admission and after an interval of 15 days. The ejection fraction measured at admission and 15 days after admission was having a significant correlation with the measured serum soluble ST2 at the time of admission [having a p value of 0.00(<0.05)].
Authors and Affiliations
Dr. Rishi Tuhin Guria MD, Dr. Sujeet Marandi MD, Dr. Mayank Srivastava MD
Keywords
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