Relationship between serum PD-L1 levels and prognosis of gastric cancer patients
Journal Title: Journal of Surgery : Concepts & Practice - Year 2024, Vol 29, Issue 3
Abstract
[Objective] To analyze the serum PD-L1 levels of gastric cancer patients and its relationship with tumor stage and prognosis. [Methods] Serum of sixty patients with pathological diagnosis of gastric cancer in our hospital from August 2018 to December 2019 were collected, and the serum of 15 healthy adults as a control. The serum PD-L1 levels was measured by enzyme linked immunosorbent assay(ELISA). The serum PD-L1 levels between gastric cancer patients and healthy adults were compared.The relationship between the serum PD-L1 levels and prognosis of gastric cancer patients with different stages was analyzed. Finally, the PD-L1 expression in tumor tissues was detected by immunohistochemical staining, and its correlation with serum PD-L1 levels was analyzed.[ Results] The serum PD-L1 levels of gastric cancer group was significantly higher than that of the control group. The serum PD-L1 levels in patients with stage Ⅲ and Ⅳ gastric cancer was significantly higher than that in stage Ⅰ and Ⅱ. The serum PD-L1 levels in gastric cancer patients with peritoneal metastasis was significantly elevated, indicating poor prognosis. Kaplan-Meier survival analysis showed that the survival time of gastric cancer patients with higher level of serum PD-L1 was shorter than those with lower ones. We further evaluated the PD-L1 expression in tumor tissues. There was no significant correlation between the serum PD-L1 levels and that in tumor tissues. [Conclusions] The serum PD-L1 levels of gastric cancer patients was higher than that of healthy adults, and which gradually increased with the progression of the disease. Gastric cancer patients with peritoneal metastasis had a much higher serum PD-L1 levels, and there was no significant correlation between serum PD-L1 levels and PD-L1 expression in tumor tissues.
Authors and Affiliations
Changqiang CHEN, Xiaowei YAN, Jiele HU, Xiting BAO, Ming XIANG, Songyao JIANG
Keywords
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- EP ID EP750969
- DOI 10.16139/j.1007-9610.2024.03.08
- Views 54
- Downloads 1
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