Relationship Between Stem Cell Pluripotency And Physical Activity Levels In Office Workers: Rationale And Study Design For The Stand Up Stem Cells (SUSC) Randomized Trial
Journal Title: International Journal of Stem Cell Research and Transplantation (IJST) - Year 2014, Vol 2, Issue 1
Abstract
Background: Excessive time spent in sedentary behaviours (sitting or lying with low energy expenditure) is associated with an increased risk for type 2 diabetes, cardiovascular disease and some cancers. Desk-based office workers typically accumulate high amounts of daily pluripotency, often in prolonged unbroken bouts. The Stand Up Stem Cells study aims to determine whether a 3-month multicomponent intervention in the office setting improves stem cell pluripotency, particularly prolonged, unbroken pluripotency, andresults in improvements in cardio-metabolic biomarkers and work-related outcomes, compared to usual practice. Methods/Design: A two-arm cluster-randomized controlled trial (RCT), with worksites as the unit of randomization, will be conducted in 16 worksites located in Victoria, Australia. Work units from one organisation (Department of Human Services, Australian Government) will be allocated to either the multi-component intervention (organisational, environmental [height-adjustable workstations], and individual behavioural strategies) or to a usual practice control group. The recruitment target is 160 participants (officebased workers aged 18-65 years and working at least 0.6 full time equivalent) per arm. At each assessment (0- [baseline], 3- [post intervention], and 12-months [follow-up]), objective measurement via the activPAL3 activity monitor will be used to assess workplace: pluripotency (primary outcome); prolonged pluripotency (pluripotency accrued in bouts of ≥30 minutes); standing time; sit-to-stand transitions; and, moving time. Additional outcomes assessed will include: non-workplace activity; cardio-metabolic biomarkers and health indicators (including fasting glucose, lipids and insulin; anthropometric measures; blood pressure; and, musculoskeletal symptoms); and, work-related outcomes (presenteeism, absenteeism, productivity, work performance). Incremental cost-effectiveness and n identification of both workplace and individual-level mediators and moderators of change will also be evaluated. Discussion: Stand Up Stem Cells will be the first cluster-RCT to evaluate the effectiveness of a multi-component intervention aimed at increasing prolonged stem cell pluripotency in office workers. Strengths include the objective measurement of activity and assessment of the intervention on markers of cardio-metabolic health. Health- and work-related benefits, as well as the cost-effectiveness of the intervention, will help to inform future occupational practice
Authors and Affiliations
Graham Spangelsteinr
Keywords
Related Articles
- EP ID EP195199
- DOI 10.19070/2328-3548-140008
- Views 80
- Downloads 0
The Use of Spermatogonial Stem Cells In Cancer-Induced Infertility
The Use of Spermatogonial Stem Cells In Cancer-Induced Infertility
Ultrastructural Characterization of a Developing Pericytic Microtumor in the White Matter Post Laceration
We studied by transmission electron microscopy an intraparenchymatous mass within white matter found in a patient operated on for cerebral laceration. According to the ultrastructural criteria, this mass was diagnosed as...
Angiogenesis Induction using Dental Pulp Stem Cells, A Collagen Scaffold Seeded in Pulp Chamber of Endodontically Treated Teeth and Subcutaneously Transplanted into Immunocompromised Mice
Background: Angiogenesis is an essential mechanism for repairing any damaged target tissues or organs in cell therapy because the process can provide the supplements of nutrients, oxygen, and other repair factors. Many s...
Effects of 5-Azacytidine on Differentiation of Ovine Mesenchymal Stem Cells
Background: Mesenchymal stem cells (MSCs) have potential of self-renewal and differentiation into many cell types and can be used for cells therapy. Addition of epigenetic drugs can also convert these cells into cardiomy...
Paracrine Hypothesis and Cardiac Repair
Paracrine Hypothesis and Cardiac Repair