RELATIONSHIP BETWEEN THE JNK PATHWAY AND APOPTOSIS IN HEART FAILURE.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 3
Abstract
JNKs belong to mitogen activated protein kinases family and are involved in regulation of various cellular responses including cell survival, cell proliferation and differentiation. They can be activated by several factors such as radiation, stress, growth factors , cytokines and extracellular signals. JNKs activation results in phosphorylation of downstream molecules involve in normal cellular processes. Furthermore the recent data have linked JNK signaling with different pathological coditions, including inflammation, cancer , neurodegenrative disease and cardiac hypertrophy. Gq signaling initiates hypertrophic growth of neonatal rat cultured myocytes and is postulated to transduce in vivo cardiac pressure overload hypertrophy.however with the over expression of c-jun through Ap-1 and ATF-2 transcripting factor, it can cause decompensatory hypertrophy which can proceed to cardiac failure. This review analyzes our present understanding of the role of JNK in apoptotic signaling in heart failure and some other mechanism which induces apoptosis in cardiomyocytes.
Authors and Affiliations
Zhao Junpeng, Tian Guozhong, Ahmad Zaki Barati, Santosh Adhikari.
Keywords
Related Articles
- EP ID EP536390
- DOI 10.21474/IJAR01/8647
- Views 67
- Downloads 0
GASTRIC MUCOSAL CHANGES IN DUODENAL SWITCH OPERATION IN MANAGEMENT OF MORBID OBESITY:PRE- AND POST-OPERATIVE COMPARISON.
Objectives: Duodenal switch has proved to be the most effective procedure in management of morbid obesity as it has long-term weight loss outcome and co-morbidity improvement.It is important to study the types of abnorma...
OCCURANCE OF ULCERATIVE ENTERITIS IN ADULT JAPANESE QUAILS.
Ulcerative enteritis (UE) was diagnosed in 10 week old Japanese quail based on gross, microscopic lesions and cultural examination of the quails submitted for necropsy. The size of flock was 1000 and the quail were kept...
CHALLENGES TO IMPLEMENT PROPER ACCOUNTING PRACTICES IN MICRO AND SMALL SCALE ENTERPRISES (MSE), IN CASE OF WOLAITA SODO TOWN, ETHIOPIA.
The importance of maintaining proper books of accounts and accurate accounting practices have been emphasize in ensuring proper financial management in SME. This study, examines challenges that affect the application of...
PHYTOCHEMICAL ANALYSIS OF TRIKATU CHURNA.
Trikatu churna is an ayurvedic polyherbal formulation of pippali, sunthi, marich whose botanical names are Piper longum Linn, Zingiber officinale, Piper nigrum Linn respectively. It has been used in diseases like agniman...
THE ROLE OF CHLORINATED PARAFFIN WITH EPOXY RESIN FABRIC AS ANTIBIOTIC PLASTIC.
In this paper , the chlorinated paraffin was added to epoxy resin fabric with different weight percentage ratios (1%,3%,5%,7%,10%, 15% ) . All samples were molded in traditional mold ,and they were milled as a powder in...