Relationship of cerebrospinal fluid choline acetyltransferase and cholinesterase with 〖JP〗postoperative delirium in elderly patients
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 4
Abstract
"<b>Objective</b> To detect the concentrations of choline acetyltransferase (ChAT) and cholinesterase (ChE) in cerebrospinal fluid of elderly patients and explore their relationship with postoperative delirium (POD). <b>Methods</b> One hundred and eighty-three patients who underwent total knee/total hip arthroplasty at Qingdao Municipal Hospital from September 2018 to August 2019 were included. All patients underwent total knee or total hip arthroplasty, using combined spinal-epidural anesthesia. After subarachnoid puncture, 2 mL of cerebrospinal fluid (CSF) was extracted. Enzyme-linked immunosorbent assay was used to detect the concentration of ChAT, ChE, tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) in CSF, and spectrophotometry was used to detect the activity of ChAT and ChE in CSF. The occurrence of POD was assessed using the Confusion Assessment of Method (CAM) after surgery. <b>Results</b> Among 183 patients, 157 cases without POD were as non-POD group and 26 cases with POD were as POD group, with an incidence rate of 14.21%. In the POD group, the preoperative CSF ChE concentration ［(31.99±2.78) vs (40.89±4.19)〖LM〗 ng/mL, t=13.915, P＜0.01］ significantly reduced, while ChAT ［(1.26±0.12) vs (0.86±0.15) ng/mL, t=12.920, P＜0.01］, 〖JP2〗TNF-α［(17.19±1.32) vs (12.29±1.64) pg/mL, t=14.467, P＜0.01］, 〖JP〗and IL-6［(33.98±5.02) vs (16.98±3.41) pg/mL, t=16.643, P＜0.01］ significantly increased compared to the non-POD group. In the POD group, the preoperative CSF ChE activity significantly reduced ［(4.28±0.52) vs (5.25±0.26) u/mL, t=9.321, P＜0.01］, while ChAT activity significantly increased ［(0.36±0.05) vs (0.27±0.03) u/mL, t=8.916, P＜0.01］ compared to the non-POD group. <b>Conclusion</b> The high activity of ChAT and low activity of ChE in CSF are related to the occurrence of POD in elderly patients, with cholinergic degradation closely related to its occurrence."
Authors and Affiliations
LIU Chen*, LI Xiaoxuan, BI Yanlin, LIN Xu, WANG Bin, QI Feng
Keywords
Related Articles
- EP ID EP734602
- DOI 10.13429/j.cnki.cjcr.2024.04.005
- Views 49
- Downloads 0
Relationship of cerebrospinal fluid choline acetyltransferase and cholinesterase with 〖JP〗postoperative delirium in elderly patients
"<b>Objective</b> To detect the concentrations of choline acetyltransferase (ChAT) and cholinesterase (ChE) in cerebrospinal fluid of elderly patients and explore their relationship with postoperative delirium (POD)....
Short-term efficacy and safety of sintilimab combined with oxaliplatin and capecitabine as neoadjuvant therapy for locally advanced gastric cancer
"<b>Objective</b> To investigate the short-term efficacy and safety of sintilimab combined with oxaliplatin and capecitabine(CapeOX) chemotherapy as neoadjuvant therapy for locally advanced gastric cancer. <b>Methods</...
Short- and long-term effects of microwave ablation and radiofrequency ablation on nodule volume and thyroid function in patients with benign thyroid nodules
"<b>Objective</b> To explore the short- and long-term effects of microwave ablation (MWA) and radiofrequency ablation (RFA) on thyroid nodule volume and thyroid function in patients with benign thyroid nodules (BTN). <...
Genetic causes of isolated congenital heart disease
The genetic mechanism of congenital heart disease (CHD) is complex and currently lacks a clear understanding. Literature studies on CHD often report the presence of concurrent extracardiac anomalies, but since the majori...
Efficacy of different combinations of antihypertensive drugs in patients with nocturnal hypertension
<b>Objective</b> To observe the efficacy of different combinations of antihypertensive drugs in patients with nocturnal hypertension (NH), and provide reference for clinical work. <b>Methods</b> A cross-sectional stu...