Relationship of Seminal plasma Total Antioxidant Capacity (TAC) with LH and FSH Levels in Serum with Sperm Function Parameters in Different Groups of Infertile Men
Journal Title: Iraqi Journal of Embryos and Infertility Researches - Year 2018, Vol 8, Issue 1
Abstract
Background: Oxidative stress (OS) plays a vital role in human reproduction. It rises as a consequence of excessive reactive oxygen species (ROS) production and/or reduced total antioxidant capacity (TAC) protection. Oxidative stress me- diated damages to the plasma membrane of the spermatozoa may account for de- fective spermatozoa function parameters that are observed in a high percentage of infertile patients. Objectives: This study aimed to evaluate the relationship between level of sem- inal plasma TAC in relevance to luteinizing hormone (LH) and follicle stim- ulating hormone (FSH) in serum with the assessment of routine spermatozoa parameters in different groups of infertile men. Subjects,Materials and Methods: Blood and semen samples were collected from the infertile and fertile subjects. The total number of samples were (80), the in- fertile men were divided into three groups (azoospermic, oligozoospermic and asthenozoospermic) each with (20) sample, and (20) as fertile men. Then the lev- els of serum hormones and seminal plasma TAC were measured using Enzyme Linked Immunosorbent Assay (ELISA). Results: The results of hormonal levels in serum showed that there were highly significant difference (P<0.001) in the levels of FSH and LH between control group and infertile groups. In this study its appear that there were a highly signif- icant (p<0.001) difference in the level of TAC between study groups and control group which were increased among normozoospermic men and decreased among infertile groups. The lower limit of TAC were seen in asthenozoospermic men. The results of this study also showed that there were a relationship between TAC of seminal plasma and hormonal levels, it is appear that TAC are negatively cor- related with LH and FSH. Conclusions: From the results obtained it could be concluded that; LH and FSH have an effect on male fertility via regulation of seminal plasma TAC. On the other hand seminal plasma TAC are negatively correlated with the number of im- motile spermatozoa and positively correlated with concentration, progressively motile and morphologically normal spermatozoa.
Authors and Affiliations
Fahad D. Oleiwi, Hayder A. L. Mossa, Mohammad O. Selman
Keywords
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