Relationship of vascular endothelial growth factor expression and microvessel density with clinicopathological features of triple-negative breast cancer
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 10
Abstract
"Objective To detect the expression of vascular endothelial growth factor (VEGF) and microvessel density in cancer tissues of breast cancer patients, and to analyze their relationship with clinicopathological characteristics of breast cancer. Methods Ninety-six breast cancer patients treated at the Fourth Affiliated Hospital of Nanjing Medical University from December 2021 to December 2022 were selected as the research subjects. According to whether the pathology was confirmed as triple-negative breast cancer (TNBC), they were divided into the TNBC group (24 cases) and the non-TNBC group (72 cases). Immunohistochemistry was used to detect the expression of VEGF protein in breast cancer tissues, and microvessel density was evaluated by immunohistochemical labeling of endothelial cells followed by counting the number of microvessels. The relationship between the two and the clinicopathological characteristics of breast cancer was analyzed. Results The positive rate of VEGF in TNBC patients(66.67%) was higher than that in non-TNBC patients (25.00%), with a significant difference (χ<sup>2</sup>=13.662, P＜0.01); the microvessel density in TNBC patients（66.04±10.29) was higher than that in non-TNBC patients (61.07±10.36), with a significant difference (t=2.039, P=0.044). In the TNBC group, the positive expression rate of VEGF in patients with clinical stage Ⅰ-Ⅱ and no lymph node metastasis was significantly lower than that in patients with clinical stage Ⅲ and lymph node metastasis (P＜0.05), and the microvascular density in patients with tumor diameter≥2 cm and clinical stage Ⅲ was significantly higher than that in patients with tumor diameter＜2 cm and clinical stage Ⅰ-Ⅱ (P＜0.05). In non-TNBC group, there was no significant difference in VEGF positive expression rate and microvessel density between patients with different clinicopathological characteristics (P＞0.05). Conclusion In TNBC patients, the high expression of VEGF and the increase of microvessel density are related to the tumor diameter, clinical stage and lymph node metastasis of TNBC, which is helpful to predict the prognosis of patients and provide a new way to target VEGF pathway or microvessel therapy."
Authors and Affiliations
ZHAO Benxin, WANG Fei, LIU Pei, HAN Rongbo
Keywords
Related Articles
- EP ID EP749051
- DOI -
- Views 22
- Downloads 0
Effect of different administration methods of esketamine on postoperative pain after thoracoscopic lung surgery
Objective To investigate the effect of itravenous injection or infuson of esketamine on postoperative pain in patients undergoing thoracoscopic lung surgery. Methods A total of 90 patients who underwent elective thorac...
Advances in the role of T cells in colorectal cancer and related therapies
T cells are closely associated with tumor development and the homeostasis of the tumor microenvironment (TME). The co-receptors of immune checkpoints on the surface of T cells collectively regulate immune responses and c...
Effect of clearing stomach and strengthening spleen on serum neuropeptide Y and leptin in patients with simple obesity
<b>Objective</b> To explore the effects of clearing the stomach and strengthening the spleen in the treatment of simple obesity on serum neuropeptide Y (NPY) and leptin from the perspective of spleen and stomach. <b>Meth...
Influencing factors of pathological complete response in triple-negative breast cancer with neoadjuvant chemotherapy
Objective To analyze the clinical and pathological factors affecting pathological complete response (pCR) of triple-negative breast cancer (TNBC) after neoadjuvant chemotherapy (NAC). Methods A retrospective analysis wa...
Evaluation of plasma atherogenic index on short-term prognosis of intravascular interventional therapy in patients with acute ischemic stroke
Objective To explore the role of plasma atherosclerotic index (AIP) in evaluating the short-term prognosis of endovascular intervention in acute ischemic stroke (AIS) patients of different age groups. Methods From Janu...