RELAXANT EFFECT OF VINCAMINE HYDROCHLORIDE AND PYROZALIN IODIDE ALKALOIDS ON AORTIC SMOOTH MUSCLE CELLS VIA CA2+ L-CHANNELS
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 11
Abstract
In this study, the results of the effects of vincamine hydrochloride and pyrozalin iodide alkaloids on the relaxation of aortic smooth muscle cells in the presence of Ca2+ L-channels have been reported. The isometric contraction activity of the aortic blood vessel smooth muscle derived from rabbits was studied using mechanography. The results, under in vitro conditions, demonstrated that the contraction activity of the rabbit aortic blood vessel smooth muscle preparation induced by 50 mM KCl was dependent on the potential of the plasma membrane, associated with the activity of the Ca2+L-channels. It was found that vincamine and pyrozalin iodide alkaloids had an effect on the blockage of the Ca2+L-channels and a reduction in [Ca2+] concentration. The obtained results suggest that the relaxing effect of vincamine hydrochloride and pyrozalin iodide alkaloids is based on the blockage of the L-type Ca2+ channels, and they also affect the receptor-operated Ca2+ channels. In conclusion, the results indicate that in providing the relaxing effect of vincamine and pyrozalin iodide alkaloids, the blockage of potential-dependent L-type Ca2+ channels, along with the blockage of receptor-operated Ca2+ channels, plays an important role.
Authors and Affiliations
Allaniyazova Zuxra Durisbergen qizi, Adilbekov Takhir Tukhtaevich, Usmanov Pulat Bekmuradovich, Yuldashev Nasirdjan Mukhamedjanovich
Keywords
Related Articles
- EP ID EP725087
- DOI 10.5281/zenodo.10251461
- Views 45
- Downloads 0
JAPAN'S TOURISM POTENTIAL AND REGULATORY FRAMEWORK FOR TOURISM DEVELOPMENT IN JAPAN
Japan is one of the most developed countries in the world with a thousand-year history, unique culture and traditions. This country, known to the world as "Japan", is actually called "Nihon Koku". The name is official, u...
REALIZATION OF SEMANTICS OF SUBJECTIVE ATTITUDE IN ENGLISH AND UZBEK LANGUAGES THROUGH SIMILES AND METAPHORS
It is known that the stylistic means "similes" appear as a product of a unique figurative way of thinking. They serve for the expressiveness of speech. In different peoples, it is possible to see the use of a certain t...
COMPOSITION OF BIOLOGICALLY ACTIVE COMPOUNDS IN APIUM GRAVEOLENE PLANT EXTRACT
This article describes the qualitative analysis of the chemical composition of Apium graveolen.
ISSUES OF HISTORICAL AND MODERN FORMS OF BUSINESS TERMS
The field of terminology is one of the most urgent issues of linguistics, and this field has an ancient history. As each science or field develops, it can be observed that the terms and terms in it change and update. Thi...
OPTIMIZATION OF COGNITIVE DISORDERS IN DEMENTIA USING THE NEUROFEEDBACK THERAPY
Dementia is a syndrome caused by an organic lesion of the brain and characterized by disorders in the manistic and other cognitive spheres, including speech, orientation, abstract thinking, and praxis. These violations s...