Relevance of Serum Interleukin-1α and Interleukin-1β in Thyroid Diseases
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2014, Vol 16, Issue 1
Abstract
It has been hypothesized that cytokines which play major role as inflammatory mediators might serve as triggers of chronic inflammation and increase the risk of developing thyroid cancer. Studies have shown that Interleukin-1 (IL-1) family of cytokines are primarily associated with inflammation. Thus, the aim of present study was to estimate serum levels of Interleukin-1α (IL- 1α) and Interleukin-1β (IL-1β) from total 69 patients with different thyroid diseases: Goitre (N=21), Autoimmune diseases (N=16) and Carcinomas (N=32) and 19 healthy individuals by Enzyme Immunoassay (EIA). Results indicated that serum IL-1α was predominantly higher only in patients with goitre, while serum IL-1β was significantly elevated in patients with goitre, autoimmune diseases and thyroid carcinomas as compared to that of healthy individuals. Moreover, in thyroid carcinoma patients, inverse correlations of serum IL-1α levels with tumor size, lymphatic permeation and differentiation status were significant and serum IL-1β values were positively correlated with the lymphnode metastasis and the differentiation status of the tumors. Thus, both IL-1α and IL-1β seem to have a role in pathogenesis of thyroid diseases and monitoring their serum levels can be distinctively helpful in differentiating patients with thyroid disease from healthy subjects. Also the differential strategy of IL- 1α and IL-1β in malignant cells or in the tumor's microenvironment can open new avenues for using IL-1 in cancer therapy.
Authors and Affiliations
Toral Kobawala, Nandita Ghosh, Trupti Trivedi, Kinjal Gajjar, Premal Thakor, Urvi Parekh, Girish Patel, Geeta Joshi
Keywords
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