Reliability of Toluidine blue stain in diagnosis of oral cancer and precancer: Database study
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 8
Abstract
Early diagnosis is the single most factors that improve the prognosis and survival rate of cancer patients. Numerous adjuncts are available to aid in its diagnosis. Vital tissue staining using Toluidine blue is one such key adjunct used in the diagnosis of cancer. Toluidine blue is a basic metachromatic stain that demonstrates affinity for DNA and RNA. It offers a potentially simple, inexpensive, and sensitive chair-side solution for screening of early oral squamous cell carcinoma and high-grade dysplasias. Aim and objective: The aim of this study is to provide a comprehensive review on accuracy of toluidine blue stain in oral cancers and precancer. Materials and methods: Literature search was performed using Pubmed, google scholar, ICMJE from past 5 years research based on efficacy of Toluidine blue staining as diagnostic aid in oral cancer and precancer cases. Sensitivity and specificity, as well as positive and negative predictive values for the toluidine blue, were calculated. Results: Toluidine blue stain is expected to be a reliable aid when clinical examination is unable to differentiate lesions at high risk of progression and hence, improving early diagnosis for oral cancer and precancer.
Authors and Affiliations
Dr. Pradkhshana Vijay
Keywords
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