Remedial effects of aged Garlic extract during acute and chronic arsenic exposure in mice
Journal Title: International Journal of Experimental Research and Review - Year 2016, Vol 6, Issue 5
Abstract
Regular oral supplementation of aged Garlic (Allium sativum L.) extract during acute (5mg/kg body weight at a time, intraperitoneally, for five days) and chronic arsenic exposures (0.2 mg/kg body weight, intraperitoneally, weekly for 12 weeks) to Swiss albino mice was investigated. Bradford assay and gel electrophoresis study exhibited that the total protein contents in some tissues had decreased by the arsenic toxicity, but revived by garlic supplementation. In vitro study revealed that the inhibition of the activities of some enzymes like lipid peroxidase, acid phosphatase and alkaline phosphatase, extracted from arsenic-treated liver, kidney, spleen and thymus tissues was reversed by the incubation of the said tissues with garlic extract. The atomic absorption spectrometric study displayed that the arsenic accumulation in garlic-fed mice was much less compared to that in unfed mice. These results elucidated the promising role of garlic against arsenic toxicity.
Authors and Affiliations
Tapan Kumar Pal; Sachi Nandan Kundu
Keywords
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