RENAL CLEARANCE AND URINARY EXCRETION OF MOXIFLOXACIN IN HEALTHY MALE VOLUNTEERS
Journal Title: Matrix Science Pharma (MSP) - Year 2018, Vol 2, Issue 1
Abstract
Moxifloxacin is a 4th generation fluoroquinolone. Study was planned on renal clearance and urinary excretion of moxifloxacin on healthy male volunteers by applying sensitive, rapid and accurate HPLC-UC analytical method. For this study 8 healthy male subjects similar in all physical conditions were selected. Moxifloxacin (Avelox® 400 mg) was administered orally under fasting conditions. First sample of urine and blood was collected before administration of moxifloxacin and other samples of blood were taken at 0.5, 1.5, 2.5, 3.5 hr and urine samples were withdrawn at 1, 2, 3, 4, 6, 8, 10, 12, 24, 36 and 48 hr. The pH of the samples was measured by pH meter. Blood and urine samples were analyzed with HPLC for drug determination. Endogenous creatinine was measured by reagent kit method. The plasma concentration of endogenous creatinine and drug were 12.61 ± 0.85 µg/mL and 1.678 ± 0.062 µg/mL. The renal clearance of endogenous creatinine ranges from 1.17 to 3.18 ml/min/kg with an average ± SE value of 2.67 ± 0.24 mL/min/Kg. Renal clearance of moxifloxacin was 0.476 ± 0.04 mL/min/Kg ranged between 0.27 – 0.609 mL/min/Kg. Urinary excretion of moxifloxacin calculated as cumulative percent dose excreted 20.48 ± 0.88. A positive relationship was found between diuresis and renal clearance of drug indicated that besides glomerular filtration passive diffusion is also involved at kidney tubular level.
Authors and Affiliations
Asia Farid, Tanweer Khaliq,, Hafiz Alam Sher,, Atifa Mushtaq, Abdullah Abid
PHYTOCHEMICAL AND ANTIOXIDANT SCREENING OF CASSIA ANGUSTIFOLIA, CURCUMA ZEDOARIA, EMBELIA RIBES, PIPER NIGRUM, ROSA DAMASCENA, TERMINALIA BELERICA, TERMINALIA CHEBULA, ZINGIBER OFFICINALE AND THEIR EFFECT ON STOMACH AND LIVER
Herbal medicinal natural plants and species are mostly used for wide purposes in Pakistan in current situation. There are diverse variety of phytochemical constituents which are present in plants and act as secondary met...
TETANUS IN A SURGICALLY CASTRATED BEETAL BUCK: A CASE REPORT
Tetanus is a fetal disease of human and animals caused by spore forming, Gram-positive, anaerobic bacterium Clostridium tetani. In present report, a 16-month old, Beetal buck, weighing about 40 kg was presented to outdoo...
Prevalence of Ectoparasitic Fauna and Ef�icacy of Two Commercial Acaricides against Argus persicus in Layer Poultry
Ectoparasites are responsible to transmit many bacterial and viral diseases in laying hens. A number of chemicals are used to manage tick infestation in laying birds. These include carbamates, avermectins, herbal product...
Lipid lowering effect of synthetic phenolic compound in a high- fat diet (HFD) induced hyperlipidemic mice
Hyperlipidemia is the major risk factor of arteriosclerosis, coronary heart diseases and death. Phenolic compounds have been shown to offer the protection against cardiovascular complications. In the present study, we st...
Biomedical Importance of Cocoa (Theobroma cacao): Significance and Potential for the Maintenance of Human Health
Plants and herbs have been the source of medication for man from centuries ago. Many compounds have been extracted from them for treatment of chronic diseases such as cocaine from cocoa. The Cocoa tree belongs to the fam...