Renal function derangements in hypothyroidism: A clinical correlation between serum creatinine, urea and uric acid levels
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 4
Abstract
Thyroid hormones TH are essential for an adequate development and kidney maturity The dysfunction of thyroid causes striking changes in glomerular and tubular capacities and electrolyte and water homeostasis Hypothyroidism is affiliated with a decline in glomerular filtration hyponatremia and a modification of the capacity for water extraction Since various renal function derangements occur in hypothyroidism therefore present study has been intended to determine the various parameters urea creatinine and uric acid related to renal function in hypothyroid patients and correlation of these parameters with thyroid hormones T3 T4 TSH The study was conducted on 200 hypothyroidisms Age and sex matched healthy euthyroids were selected for the study Serum was taken from each patient and control and was analyzed for T3 by competitive analogbased immunoassay T4 by competitive analogbased immunoassay TSH by 2 site chemiluminescent immunometric assay creatinine by modified Jaffes method urea by urease method and uric acid by uricase method respectively A total number of 300 cases that includes 200 hypothyroid patients 25 males and 75 females and 100 controls 42 males and 58 females were examined The mean level of serum T3 1968 01195 pgml serum T4 10152 01235 pgml serum urea 33 5570mgdl of hypothyroids were significantly lower as compared to mean level of serum T3 3704 01699 pgml serum T4 15764 016230 pgml and serum urea 3512 3710mgdl of euthyroids The mean level of serum TSH 8928 09589IUml serum Creatinine 2192 02566mgdl and serum uric acid 4224 06554mgdl of hypothyroids were significantly higher as compared to mean level of serum TSH 306 04110 IUml serum Creatinine 0852 01396 mgdl and serum uric acid 3772 02975 mgdl of euthyroids Hypothyroids serum T3 significantly correlated with positive person serum uric acid r 0343 Hypothyroids serum T4 indicate noteworthy negative Pearson relationship with serum urea r 0367 and creatinine r 0267 Hypothyroids serum TSH indicate huge negative Pearson connection with serum uric acid r 0190 and creatinine r 0344 Elevated serum creatinine serum urea and serum uric acid demonstrates renal capacity disturbances in hypothyroidism Keywords Thyroid hormones T3 T4 TSH Serum creatinine Serum uric acid
Authors and Affiliations
Raj Kumar, Ajay Kumar Singh, Ashish Sharma, Dharambeer Sharma, Saurabha Srivastava
Keywords
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- EP ID EP475425
- DOI 10.18231/2394-6377.2018.0113
- Views 67
- Downloads 0
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