Renal Integrity Probably Determines Tolerance to Infection with Trypanosoma congolense in Rats and Natural Hosts
Journal Title: Annual Research & Review in Biology - Year 2016, Vol 11, Issue 1
Abstract
Aim: The research was carried out to determine the role of renal function in susceptibility to anemia in rats infected with Trypanosoma congolense. Study Design: The study utilized a total of twenty-four (24) male albino rats, divided into two groups of eight (8) albino rats as control group and 16 albino rats to serve as infected group, inoculated intraperitoneally with T. congolense (1×103 parasites). Place and Duration of Study: The study was carried out in the Department of Veterinary Pathology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria. Methodology: The study involved determination of parasitaemia, post infection derangements in hematology and serum urea and creatinine levels of rats. Results: T. congolense precipitated an acute, severe and fatal infection in rats characterized by, anemia, and renal dysfunction, leading to death. At the end of 2 weeks post infection (PI), anemia characterized by drop in the packed cell volume (PCV), was found to be significantly higher in rats infected with T. congolense, compared to the rats in the control group. The PCV of control rats fluctuated within normal range. Serum biochemical changes included elevation in levels of blood urea nitrogen (BUN) and creatinine. The anemia was severer in rats with higher increases in BUN and creatinine levels. Conclusion: The study points to early development of renal pathology and subnormal erythropoietin production as some of the important factors behind dyserythropoiesis and crippling effect of anemia in T. congolense infections. Early renal pathology may be an important antigenic property that determines severity of anemia and tolerance in Trypanosoma congolense infections.
Authors and Affiliations
J. N. Abenga, E. T. Adeniji, C. O. Ezihe
Keywords
Related Articles
- EP ID EP351089
- DOI 10.9734/ARRB/2016/23866
- Views 65
- Downloads 0
Oil-bioactive Films as an Antifungal Application to Save Post-harvest Food Crops
Background: Agricultural wastes were rich in many components, which may considered as a source of natural and active materials. This study was targeted to apply a non-traditional method to safe grains against toxigenic f...
Osmotic Stress Effect on Different Cytological Characters of Roots and Growth Parameters in Different Wheat Species
Aims: To show how and why seedling growth parameters and different cytological characters of the roots of different wheat species may vary during osmotic stress conditions. To identify species that are tolerant to a lack...
Evaluation of Bast Fibres of the Stem of Carica papaya L. for Application as Reinforcing Material in Green Composites
Aims: The production of green composites based on natural fibres is rising with regard to increasing environmental problems and declining fossil raw materials. Bast fibres of papaya (Carica papaya L.) accumulate on plant...
Psychoneuroendocrinology Aspect of Sleep Pattern in Women with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common complex condition in women associated with reproductive, metabolic and psychological features. PCOS is the most common endocrine disorder in the reproductive age of women. The...
Role of Interstitial Angiotensin II and ATP in Mediating Renal Injury Induced by Recurrent Insulin Induced Hypoglycemia
Aim: The present study hypothesizes that recurrent insulin induced hypoglycemia (RIIH) elevates renal interstitial ATP levels which in turn enhances AngII production. This interrupts the normal tubuloglomerular feedback...