Repolarization Parameters in Patients with Premature Coronary Artery Disease
Journal Title: Journal of Ankara University Faculty of Medicine - Year 2019, Vol 72, Issue 1
Abstract
Objectives: Coronary artery disease (CAD) in young adults is relatively rare. Few data on CAD in young adults are available in the literature. In the current study, repolarization parameters were evaluated in patients with newly diagnosed premature CAD. Materials and Methods: A total of 200 patients [128 male, 38.0 (29.3-42.0) years] were included and 100 cases with newly diagnosed premature coronary heart disease (aged ≤45 years) formed the study group. Remaining 100 cases were well-matched controls. Repolarization parameters including QTc interval, Tp-e interval and Tp-e∕QTc in leads DII, V2 and V6 were compared between the two groups. Results: The median QTc interval (430.3 ms vs 405.3 ms, p<0.001) in lead D2, (433.8 ms vs 404.7 ms, p<0.001) in lead V2 and (430.2 ms vs 401.7 ms, p<0.001) in lead V6; the median Tp-e interval (80 ms vs 64 ms, p<0.001) in lead D2, (82 ms vs 74 ms, p<0.001) in lead V2 and (88 ms vs 72 ms, p<0.001) in lead V6; and the median Tp-e/QTc (0.188 vs 0.158, p<0.001) in lead D2, (0.190 vs 0.181, p=0.022) in lead V2 and (0.196 vs 0.183, p<0.001) in lead V6 were significantly higher in patients with premature CAD compared controls, respectively. Conclusion: In conclusion, premature coronary heart disease may be related to abnormal dispersion of repolarization and subsequent arrhythmic risk.
Authors and Affiliations
Firdevs Ayşenur Ekizler, Bahar Tekin Tak, Serkan Çay, Habibe Kafes, Özcan Özeke, Fırat Özcan, Dursun Aras, Serkan Topaloğlu
Keywords
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- EP ID EP48690
- DOI 10.4274/atfm.galenos.2019.63935
- Views 255
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